Next Article in Journal
Inflammatory Diseases and Growth: Effects on the GH–IGF Axis and on Growth Plate
Next Article in Special Issue
Gut Fermentation of Dietary Fibres: Physico-Chemistry of Plant Cell Walls and Implications for Health
Previous Article in Journal
Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma
Article Menu
Issue 9 (September) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(9), 1785; doi:10.3390/ijms18091785

Impact of Novel Prebiotic Galacto-Oligosaccharides on Various Biomarkers of Colorectal Cancer in Wister Rats

1
Department of Food Science and Human Nutrition, University of Veterinary & Animal Sciences, Punjab 54000, Pakistan
2
Department of Physiology, University of Veterinary & Animal Sciences, Punjab 54000, Pakistan
3
Department of Food Science, Cornell University, Ithaca, NY 14850, USA
*
Author to whom correspondence should be addressed.
Received: 21 July 2017 / Revised: 9 August 2017 / Accepted: 10 August 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Dietary Fibre: New Insights on Biochemistry and Health Benefits)
View Full-Text   |   Download PDF [791 KB, uploaded 31 August 2017]   |  

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer deaths around the globe. Bioactive food ingredients such as prebiotics have protective potential in colon cancer. Data on galacto-oligosaccharides (GalOS) against CRC are very limited and GalOS used in this study have β-1,6 and β-1,3 as major glycosidic linkages and, to our best knowledge, were never used before against any cancer treatment. This study aims to investigate the protective role of novel GalOS against various biomarkers of CRC including aberrant crypt foci (ACF), bacterial enzymes and short chain fatty acids (SCFA) in a rodent model induced with 1,2-dimethylhydrazine dihydrochloride (DMH). Inulin group was taken as positive control in present study to compare novel GalOS protective effects. GalOS doses of 76–151 mg and inulin doses of 114 mg were given to different groups treated with DMH. Results showed that ACF formation was significantly (p ≤ 0.05) less in high dose GalOS group (27.3%). GalOS also had protective effects against DMH-induced body weight loss and showed higher level of cecal and fecal SCFA (acetate, propionate and butyrate). High doses of GalOS also resulted in significant (p ≤ 0.05) reduction of bacterial enzymatic activities. Increased populations of beneficial bacteria (bifidobacteria and lactobacilli) and decreased concentrations of harmful bacteria were observed in all prebiotics treatment groups. It can be concluded that novel GalOS exhibit robust protective activity against ACF formation in vivo. View Full-Text
Keywords: galacto-oligosaccharides; colorectal cancer; aberrant crypt foci; bacterial enzymes galacto-oligosaccharides; colorectal cancer; aberrant crypt foci; bacterial enzymes
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Qamar, T.R.; Iqbal, S.; Syed, F.; Nasir, M.; Rehman, H.; Iqbal, M.A.; Liu, R.H. Impact of Novel Prebiotic Galacto-Oligosaccharides on Various Biomarkers of Colorectal Cancer in Wister Rats. Int. J. Mol. Sci. 2017, 18, 1785.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top