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Int. J. Mol. Sci. 2017, 18(8), 1819; doi:10.3390/ijms18081819

Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation

1
Department of Otorhinolaryngology, Division of Facial Plastic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany
2
Department of Plastic, Aesthetic, Hand & Reconstructive Surgery, University Hospital Regensburg, 93053 Regensburg, Germany
3
Department of Gynaecology and Obstetrics, University Medical Centre Regensburg, 93053 Regensburg, Germany
4
Department of Radiotherapy, University Hospital Regensburg, 93053 Regensburg, Germany
5
Department of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, 93053 Regensburg, Germany
6
Department of Otorhinolaryngology, University Hospital Goettingen, 37075 Goettingen, Germany
7
Department of Otorhinolaryngology, Ludwig-Maximilians-University Munich, 81377 Munich, Germany
*
Authors to whom correspondence should be addressed.
Received: 12 July 2017 / Revised: 7 August 2017 / Accepted: 17 August 2017 / Published: 22 August 2017
(This article belongs to the Special Issue Molecular Research of Epidermal Stem Cells 2017)
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Abstract

Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma. View Full-Text
Keywords: radiation therapy; human adipose-derived stem cells; microvascular endothelial cells; platelet-rich plasma radiation therapy; human adipose-derived stem cells; microvascular endothelial cells; platelet-rich plasma
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MDPI and ACS Style

Reinders, Y.; Felthaus, O.; Brockhoff, G.; Pohl, F.; Ahrens, N.; Prantl, L.; Haubner, F. Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation. Int. J. Mol. Sci. 2017, 18, 1819.

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