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Int. J. Mol. Sci. 2017, 18(8), 1723; doi:10.3390/ijms18081723

Shear Bond Strength and Remineralisation Effect of a Casein Phosphopeptide-Amorphous Calcium Phosphate-Modified Glass Ionomer Cement on Artificial “Caries-Affected” Dentine

1
Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
2
Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Received: 5 June 2017 / Revised: 13 July 2017 / Accepted: 3 August 2017 / Published: 7 August 2017
(This article belongs to the Section Biomaterial Sciences)
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Abstract

This study investigated the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP)-modified glass ionomer cement (GIC) on shear bond strength (SBS) and remineralisation of artificial “caries-affected” dentine. Human dentine slices were demineralised and allocated to three groups: group 1, conventional GIC; group 2, CPP-ACP-modified GIC; and group 3, resin-modified GIC. The SBS was measured using a universal testing machine (n = 16 per group). Remaining samples (n = 8 per group) were subjected to pH-cycling for 28 days. After pH-cycling, lesion depth and micro-mechanical properties at the sample-bonding interface were investigated using micro-computed tomography (micro-CT) and nano-indentation, respectively. The SBS for groups 1 to 3 were 4.6 ± 1.5 MPa, 4.2 ± 1.1 MPa, and 5.9 ± 1.9 MPa, respectively (p = 0.007; group 1, group 2 < group 3). Lesion depths determined by micro-CT for groups 1 to 3 were 186 ± 8 µm, 149 ± 14 µm, and 178 ± 8 µm, respectively (p < 0.001; group 2 < group 1, group 3). The mean (±SD, standard deviation) nano-hardness values for groups 1 to 3 were 0.85 ± 0.22 GPa, 1.14 ± 0.21 GPa, and 0.81 ± 0.09 GPa, respectively (p = 0.003; group 1, group 3 < group 2). The mean (±SD) elastic moduli for groups 1 to 3 were 1.70 ± 0.33 GPa, 2.35 ± 0.44 GPa, and 1.59 ± 0.13 GPa, respectively (p < 0.001; group 1, group 3 < group 2). The results suggest that the incorporation of CPP-ACP into GIC does not adversely affect the adhesion to artificial caries-affected dentine. Furthermore, CPP-ACP-modified GIC is superior to conventional GIC in promoting dentine remineralisation. View Full-Text
Keywords: casein phosphopeptide-amorphous calcium phosphate (CPP-ACP); shear bond strength; remineralisation; glass ionomer casein phosphopeptide-amorphous calcium phosphate (CPP-ACP); shear bond strength; remineralisation; glass ionomer
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MDPI and ACS Style

Zhao, I.S.; Mei, M.L.; Zhou, Z.L.; Burrow, M.F.; Lo, E.-M.; Chu, C.-H. Shear Bond Strength and Remineralisation Effect of a Casein Phosphopeptide-Amorphous Calcium Phosphate-Modified Glass Ionomer Cement on Artificial “Caries-Affected” Dentine. Int. J. Mol. Sci. 2017, 18, 1723.

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