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Int. J. Mol. Sci. 2017, 18(8), 1713; doi:10.3390/ijms18081713

Estrogen, Estrogen Receptor and Lung Cancer

1,2,3
,
4
and
1,5,*
1
Ph.D. Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan
2
Division of Pulmonary and Critical Care Medicine, Sun Yat-Sen Cancer Center, Taipei 112, Taiwan
3
Department of Medicine, National Yang-Ming University Medical School, Taipei 112, Taiwan
4
Department of Medical Oncology, Sun Yat-Sen Cancer Center, Taipei 112, Taiwan
5
School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan
*
Author to whom correspondence should be addressed.
Received: 25 June 2017 / Revised: 1 August 2017 / Accepted: 3 August 2017 / Published: 5 August 2017
(This article belongs to the Special Issue Molecular Pathways of Estrogen Receptor Action)
View Full-Text   |   Download PDF [4376 KB, uploaded 5 August 2017]   |  

Abstract

Estrogen has been postulated as a contributor for lung cancer development and progression. We reviewed the current knowledge about the expression and prognostic implications of the estrogen receptors (ER) in lung cancer, the effect and signaling pathway of estrogen on lung cancer, the hormone replacement therapy and lung cancer risk and survival, the mechanistic relationship between the ER and the epidermal growth factor receptor (EGFR), and the relevant clinical trials combining the ER antagonist and the EGFR antagonist, to investigate the role of estrogen in lung cancer. Estrogen and its receptor have the potential to become a prognosticator and a therapeutic target in lung cancer. On the other hand, tobacco smoking aggravates the effect of estrogen and endocrine disruptive chemicals from the environment targeting ER may well contribute to the lung carcinogenesis. They have gradually become important issues in the course of preventive medicine. View Full-Text
Keywords: epidermal growth factor receptor; estrogen; estrogen receptor; hormone; lung cancer; lung adenocarcinoma epidermal growth factor receptor; estrogen; estrogen receptor; hormone; lung cancer; lung adenocarcinoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hsu, L.-H.; Chu, N.-M.; Kao, S.-H. Estrogen, Estrogen Receptor and Lung Cancer. Int. J. Mol. Sci. 2017, 18, 1713.

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