Next Article in Journal
Anti-Oxidative Stress Activity Is Essential for Amanita caesarea Mediated Neuroprotection on Glutamate-Induced Apoptotic HT22 Cells and an Alzheimer’s Disease Mouse Model
Next Article in Special Issue
Tumor-Stroma Crosstalk in Bone Tissue: The Osteoclastogenic Potential of a Breast Cancer Cell Line in a Co-Culture System and the Role of EGFR Inhibition
Previous Article in Journal
Multi-Targeting Andrographolide, a Novel NF-κB Inhibitor, as a Potential Therapeutic Agent for Stroke
Previous Article in Special Issue
Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(8), 1630; doi:10.3390/ijms18081630

PGK1 Drives Hepatocellular Carcinoma Metastasis by Enhancing Metabolic Process

1
College of Traditional Chinese medicine, Jinan University, Guangzhou 510632, China
2
Department of Pathology, Guangdong Provincial Key Laboratory of Molecular Tumor Pathology and School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 16 May 2017 / Revised: 12 July 2017 / Accepted: 22 July 2017 / Published: 27 July 2017
(This article belongs to the Special Issue Chemical and Molecular Approach to Tumor Metastases)
View Full-Text   |   Download PDF [5589 KB, uploaded 27 July 2017]   |  

Abstract

During the proliferation and metastasis, the tumor cells prefer glycolysis (Warburg effect), but its exact mechanism remains largely unknown. In this study, we demonstrated that phosphoglycerate kinase 1 (PGK1) is an important enzyme in the pathway of metabolic glycolysis. We observed a significant overexpression of PGK1 in hepatocellular carcinoma tissues, and a correlation between PGK1 expression and poor survival of hepatocellular carcinoma patients. Also, the depletion of PGK1 dramatically reduced cancer cell proliferation and metastasis, indicating an oncogenic role of PGK1 in liver cancer progression. Further experiments showed that PGK1 played an important role in MYC-induced metabolic reprogramming, which led to an enhanced Warburg effect. Our results revealed a new effect of PGK1, which can provide a new treatment strategy for hepatocellular carcinoma, as PGK1 is used to indicate the prognosis of hepatocellular carcinoma (HCC). View Full-Text
Keywords: PGK1; MYC; hepatocellular carcinoma; metastasis; Warburg effect PGK1; MYC; hepatocellular carcinoma; metastasis; Warburg effect
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xie, H.; Tong, G.; Zhang, Y.; Liang, S.; Tang, K.; Yang, Q. PGK1 Drives Hepatocellular Carcinoma Metastasis by Enhancing Metabolic Process. Int. J. Mol. Sci. 2017, 18, 1630.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top