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Int. J. Mol. Sci. 2017, 18(7), 1593; doi:10.3390/ijms18071593

Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters

Laboratoire Bio-PeroxIL EA7270, University of Bourgogne Franche-Comté, 6 Bd Gabriel, 21000 Dijon, France
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Received: 26 June 2017 / Revised: 10 July 2017 / Accepted: 19 July 2017 / Published: 22 July 2017
(This article belongs to the Special Issue Physiological and Pathological Roles of ABC Transporters)
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Abstract

The peroxisomal ATP-binding Cassette (ABC) transporters, which are called ABCD1, ABCD2 and ABCD3, are transmembrane proteins involved in the transport of various lipids that allow their degradation inside the organelle. Defective ABCD1 leads to the accumulation of very long-chain fatty acids and is associated with a complex and severe neurodegenerative disorder called X-linked adrenoleukodystrophy (X-ALD). Although the nucleotide-binding domain is highly conserved and characterized within the ABC transporters family, solid data are missing for the transmembrane domain (TMD) of ABCD proteins. The lack of a clear consensus on the secondary and tertiary structure of the TMDs weakens any structure-function hypothesis based on the very diverse ABCD1 mutations found in X-ALD patients. Therefore, we first reinvestigated thoroughly the structure-function data available and performed refined alignments of ABCD protein sequences. Based on the 2.85  Å resolution crystal structure of the mitochondrial ABC transporter ABCB10, here we propose a structural model of peroxisomal ABCD proteins that specifies the position of the transmembrane and coupling helices, and highlight functional motifs and putative important amino acid residues. View Full-Text
Keywords: ATP-binding Cassette (ABC) transporters; peroxisome; fatty acid transport; topology; predictive structure; adrenoleukodystrophy ATP-binding Cassette (ABC) transporters; peroxisome; fatty acid transport; topology; predictive structure; adrenoleukodystrophy
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Andreoletti, P.; Raas, Q.; Gondcaille, C.; Cherkaoui-Malki, M.; Trompier, D.; Savary, S. Predictive Structure and Topology of Peroxisomal ATP-Binding Cassette (ABC) Transporters. Int. J. Mol. Sci. 2017, 18, 1593.

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