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Int. J. Mol. Sci. 2017, 18(7), 1511; doi:10.3390/ijms18071511

The Role of Ghrelin and Ghrelin Signaling in Aging

1
Education Center for Doctors in Remote Islands and Rural Areas, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima 890-8544, Japan
2
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
3
Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan
*
Author to whom correspondence should be addressed.
Received: 22 June 2017 / Revised: 4 July 2017 / Accepted: 7 July 2017 / Published: 12 July 2017
(This article belongs to the Special Issue Neurobiological Perspectives on Ghrelin)
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Abstract

With our aging society, more people hope for a long and healthy life. In recent years, researchers have focused on healthy longevity factors. In particular, calorie restriction delays aging, reduces mortality, and extends life. Ghrelin, which is secreted during fasting, is well known as an orexigenic peptide. Because ghrelin is increased by caloric restriction, ghrelin may play an important role in the mechanism of longevity mediated by calorie restriction. In this review, we will discuss the role of orexigenic peptides with a particular focus on ghrelin. We conclude that the ghrelin-growth hormone secretagogue-R signaling pathway may play an important role in the anti-aging mechanism. View Full-Text
Keywords: ghrelin; calorie restriction; longevity; ghrelin resistance; ghrelin agonist ghrelin; calorie restriction; longevity; ghrelin resistance; ghrelin agonist
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Amitani, M.; Amitani, H.; Cheng, K.-C.; Kairupan, T.S.; Sameshima, N.; Shimoshikiryo, I.; Mizuma, K.; Rokot, N.T.; Nerome, Y.; Owaki, T.; Asakawa, A.; Inui, A. The Role of Ghrelin and Ghrelin Signaling in Aging. Int. J. Mol. Sci. 2017, 18, 1511.

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