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Int. J. Mol. Sci. 2017, 18(7), 1487; doi:10.3390/ijms18071487

Altered Mitochondrial Metabolism and Mechanosensation in the Failing Heart: Focus on Intracellular Calcium Signaling

1
Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy
2
Institute of Genetic and Biomedical Research, National Research Council, 20138 Milan, Italy
*
Author to whom correspondence should be addressed.
Received: 31 May 2017 / Revised: 28 June 2017 / Accepted: 4 July 2017 / Published: 10 July 2017
(This article belongs to the Special Issue Mitochondria Crosstalks with other Organelles in Pathophysiology)
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Abstract

The heart consists of millions of cells, namely cardiomyocytes, which are highly organized in terms of structure and function, at both macroscale and microscale levels. Such meticulous organization is imperative for assuring the physiological pump-function of the heart. One of the key players for the electrical and mechanical synchronization and contraction is the calcium ion via the well-known calcium-induced calcium release process. In cardiovascular diseases, the structural organization is lost, resulting in morphological, electrical, and metabolic remodeling owing the imbalance of the calcium handling and promoting heart failure and arrhythmias. Recently, attention has been focused on the role of mitochondria, which seem to jeopardize these events by misbalancing the calcium processes. In this review, we highlight our recent findings, especially the role of mitochondria (dys)function in failing cardiomyocytes with respect to the calcium machinery. View Full-Text
Keywords: mechanoelectric transduction; mitochondria metabolism; calcium transient; microdomains; fatty acids mechanoelectric transduction; mitochondria metabolism; calcium transient; microdomains; fatty acids
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Cabassi, A.; Miragoli, M. Altered Mitochondrial Metabolism and Mechanosensation in the Failing Heart: Focus on Intracellular Calcium Signaling. Int. J. Mol. Sci. 2017, 18, 1487.

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