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Int. J. Mol. Sci. 2017, 18(7), 1486; doi:10.3390/ijms18071486

Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair

Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Ole Maaløes Vej 5, Copenhagen N 2200, Denmark
These authors contributed equally to this work.
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Received: 12 June 2017 / Revised: 1 July 2017 / Accepted: 4 July 2017 / Published: 10 July 2017
(This article belongs to the Special Issue Mechanisms Leading to Genomic Instability)
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Abstract

Genomic DNA is compacted into chromatin through packaging with histone and non-histone proteins. Importantly, DNA accessibility is dynamically regulated to ensure genome stability. This is exemplified in the response to DNA damage where chromatin relaxation near genomic lesions serves to promote access of relevant enzymes to specific DNA regions for signaling and repair. Furthermore, recent data highlight genome maintenance roles of chromatin through the regulation of endogenous DNA-templated processes including transcription and replication. Here, we review research that shows the importance of chromatin structure regulation in maintaining genome integrity by multiple mechanisms including facilitating DNA repair and directly suppressing endogenous DNA damage. View Full-Text
Keywords: genome maintenance; chromatin; DNA damage response; endogenous DNA damage genome maintenance; chromatin; DNA damage response; endogenous DNA damage
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Nair, N.; Shoaib, M.; Sørensen, C.S. Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair. Int. J. Mol. Sci. 2017, 18, 1486.

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