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Int. J. Mol. Sci. 2017, 18(7), 1462; doi:10.3390/ijms18071462

Effects of Titanium Mesh Surfaces-Coated with Hydroxyapatite/β-Tricalcium Phosphate Nanotubes on Acetabular Bone Defects in Rabbits

1
Department of Dental Biomaterials, Institute of Oral Bioscience and Institute of Biodegradable Material, School of Dentistry, Chonbuk National University, Jeonju 54896, Korea
2
Institute of Cell and Tissue Engineering, Department of Biomedical Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
3
Department of Orthopedic Surgery, Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeonju 54907, Korea
*
Author to whom correspondence should be addressed.
Received: 27 May 2017 / Revised: 23 June 2017 / Accepted: 4 July 2017 / Published: 7 July 2017
(This article belongs to the Collection Bioactive Nanoparticles)
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Abstract

The management of severe acetabular bone defects in revision reconstructive orthopedic surgery is challenging. In this study, cyclic precalcification (CP) treatment was used on both nanotube-surface Ti-mesh and a bone graft substitute for the acetabular defect model, and its effects were assessed in vitro and in vivo. Nanotube-Ti mesh coated with hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) was manufactured by an anodizing and a sintering method, respectively. An 8 mm diameter defect was created on each acetabulum of eight rabbits, then treated by grafting materials and covered by Ti meshes. At four and eight weeks, postoperatively, biopsies were performed for histomorphometric analyses. The newly-formed bone layers under cyclic precalcified anodized Ti (CP-AT) meshes were superior with regard to the mineralized area at both four and eight weeks, as compared with that under untreated Ti meshes. Active bone regeneration at 2–4 weeks was stronger than at 6–8 weeks, particularly with treated biphasic ceramic (p < 0.05). CP improved the bioactivity of Ti meshes and biphasic grafting materials. Moreover, the precalcified nanotubular Ti meshes could enhance early contact bone formation on the mesh and, therefore, may reduce the collapse of Ti meshes into the defect, increasing the sufficiency of acetabular reconstruction. Finally, cyclic precalcification did not affect bone regeneration by biphasic grafting materials in vivo. View Full-Text
Keywords: titanium mesh; surface modification; hydroxyapatite; β-tricalcium phosphate; bone defect; acetabular defect; total hip arthroplasty; bone tissue engineering; orthopedic surgery titanium mesh; surface modification; hydroxyapatite; β-tricalcium phosphate; bone defect; acetabular defect; total hip arthroplasty; bone tissue engineering; orthopedic surgery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nguyen, T.-D.T.; Bae, T.-S.; Yang, D.-H.; Park, M.-S.; Yoon, S.-J. Effects of Titanium Mesh Surfaces-Coated with Hydroxyapatite/β-Tricalcium Phosphate Nanotubes on Acetabular Bone Defects in Rabbits. Int. J. Mol. Sci. 2017, 18, 1462.

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