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Int. J. Mol. Sci. 2017, 18(7), 1419; doi:10.3390/ijms18071419

Diabetes and Wound Angiogenesis

1
Department of Microbiology and Immunology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA
2
Center for Wound Healing and Tissue Regeneration, University of Illinois at Chicago College of Dentistry, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Received: 30 May 2017 / Revised: 10 June 2017 / Accepted: 22 June 2017 / Published: 3 July 2017
(This article belongs to the Special Issue Wound Repair and Regeneration)
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Abstract

Diabetes Mellitus Type II (DM2) is a growing international health concern with no end in sight. Complications of DM2 involve a myriad of comorbidities including the serious complications of poor wound healing, chronic ulceration, and resultant limb amputation. In skin wound healing, which has definite, orderly phases, diabetes leads to improper function at all stages. While the etiology of chronic, non-healing diabetic wounds is multi-faceted, the progression to a non-healing phenotype is closely linked to poor vascular networks. This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis. Additionally, this review considers therapeutics that may offer promise to better wound healing outcomes. View Full-Text
Keywords: diabetes; wound healing; angiogenesis diabetes; wound healing; angiogenesis
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MDPI and ACS Style

Okonkwo, U.A.; DiPietro, L.A. Diabetes and Wound Angiogenesis. Int. J. Mol. Sci. 2017, 18, 1419.

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