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Int. J. Mol. Sci. 2017, 18(7), 1386; doi:10.3390/ijms18071386

Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus

1
Department of Molecular and Life Science, Hanyang University, 15588 Ansan, Korea
2
Institute of Natural Science and Technology, Hanyang University, 15588 Ansan, Korea
3
Department of Bionanotechnology, Hanyang University, 04763 Seoul, Korea
*
Author to whom correspondence should be addressed.
Received: 8 June 2017 / Revised: 23 June 2017 / Accepted: 26 June 2017 / Published: 28 June 2017
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
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Abstract

Ethanol is well known as a teratogenic factor that is capable of inducing a wide range of developmental abnormalities if the developing fetus is exposed to it. Duration and dose are the critical parameters of exposure that affect teratogenic variation to the developing fetus. It is suggested that ethanol interferes with epigenetic processes especially DNA methylation. We aimed to organize all of the available information on the alteration of DNA methylation by ethanol in utero. Thus, we have summarized all published information regarding alcohol-mediated alterations in DNA methylation during gestation. We tried to arrange information in a way that anyone can easily find the alcohol exposure time, doses, sampling time, and major changes in genomic level. Manuscript texts will also represent the correlation between ethanol metabolites and subsequent changes in methylome patterns. We hope that this review will help future researchers to further examine the issues associated with ethanol exposure. View Full-Text
Keywords: alcohol; epigenetics; DNA methylation; FASD; fetal development alcohol; epigenetics; DNA methylation; FASD; fetal development
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mandal, C.; Halder, D.; Jung, K.H.; Chai, Y.G. Gestational Alcohol Exposure Altered DNA Methylation Status in the Developing Fetus. Int. J. Mol. Sci. 2017, 18, 1386.

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