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Int. J. Mol. Sci. 2017, 18(6), 1262; doi:10.3390/ijms18061262

Amphotericin B, an Anti-Fungal Medication, Directly Increases the Cytotoxicity of NK Cells

1
Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
2
Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
3
Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea
4
Department of Microbiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea
*
Author to whom correspondence should be addressed.
Received: 9 May 2017 / Revised: 2 June 2017 / Accepted: 9 June 2017 / Published: 13 June 2017
(This article belongs to the Special Issue Natural Killer (NK) Cells)
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Abstract

Immunomodulatory drugs (IMiDs) present one example of immunomodulatory agents that improve cancer immunotherapy. Based on the cytotoxic activity of natural killer (NK) cells against cancer cells, a high throughput screening method for the identification of novel immunomodulatory molecules with the potential to stimulate NK cell cytotoxicity against cancer cells was designed and tested using an approved drug library. Among the primary hit compounds, the anti-fungal drug amphotericin B (AMP-B) increased the cytotoxicity of NK cell line and human primary NK cells in a direct manner. The increase in NK cell activity was related to increased formation of NK-target cell conjugates and the subsequent granule polarization toward target cells. The results of the present study indicate that AMP-B could serve a dual function as an anti-fungal and immunomodulatory drug. View Full-Text
Keywords: immunomodulatory drugs; library screening; amphotericin B; natural killer cells; cytotoxicity immunomodulatory drugs; library screening; amphotericin B; natural killer cells; cytotoxicity
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Kim, N.; Choi, J.-W.; Park, H.-R.; Kim, I.; Kim, H.S. Amphotericin B, an Anti-Fungal Medication, Directly Increases the Cytotoxicity of NK Cells. Int. J. Mol. Sci. 2017, 18, 1262.

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