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Int. J. Mol. Sci. 2017, 18(6), 1255; doi:10.3390/ijms18061255

Association of miR-938G>A Polymorphisms with Primary Ovarian Insufficiency (POI)-Related Gene Expression

1
Department of Biomedical Science, College of Life Science, CHA University, Seongnam 13488, Korea
2
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea
3
Fertility Center of CHA Gangnam Medical Center, CHA University, Seoul 06135, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 26 April 2017 / Revised: 28 May 2017 / Accepted: 7 June 2017 / Published: 12 June 2017
(This article belongs to the Collection Human Single Nucleotide Polymorphisms and Disease Diagnostics)
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Abstract

MicroRNAs (miRNAs) post-transcriptionally regulate gene expression in animals and plants. The aim of this study was to investigate whether polymorphisms in miR-938 are associated with the risk of primary ovarian insufficiency (POI) and POI-related target gene regulation. We identified the miR-938G>A polymorphisms within the seed sequence of mature miRNA and aligned the seed sequence with the 3′ untranslated region (UTR) of the gonadotropin-releasing hormone receptor (GnRHR) mRNA, a miR-938 target gene. We found that the binding of miR-938 to the 3′-UTR of GnRHR mRNA was significantly different between normal and variant alleles. Our data suggests that the dysregulation of miR-938G>A influences the binding to GnRHR and that miR-938G>A polymorphisms might contribute to regulation of POI-related target genes. View Full-Text
Keywords: single nucleotide polymorphism; microRNA; primary ovarian insufficiency; gonadotropin-releasing hormone receptor, granulosa cells single nucleotide polymorphism; microRNA; primary ovarian insufficiency; gonadotropin-releasing hormone receptor, granulosa cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Cho, S.H.; Ahn, E.H.; An, H.J.; Kim, J.H.; Ko, J.J.; Kim, Y.R.; Lee, W.S.; Kim, N.K. Association of miR-938G>A Polymorphisms with Primary Ovarian Insufficiency (POI)-Related Gene Expression. Int. J. Mol. Sci. 2017, 18, 1255.

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