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Int. J. Mol. Sci. 2017, 18(5), 899; doi:10.3390/ijms18050899

Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration

Department of Mechanical Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do 15073, Korea
Research Institute, T&R Biofab Co., Ltd., 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do 15073, Korea
Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, 49 Pusan University-Ro, Yangsan-Si, Gyeongsangnam-Do 50612, Korea
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheong-Am-Ro, Nam-Gu, Pohang-Si, Gyeongsangbuk-Do 37673, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Mohamed N. Rahaman
Received: 9 March 2017 / Revised: 17 April 2017 / Accepted: 20 April 2017 / Published: 25 April 2017
(This article belongs to the Special Issue Three-dimensional (3D) Bioprinting of Tissues and Organs)
View Full-Text   |   Download PDF [6972 KB, uploaded 25 April 2017]   |  


This study was conducted to compare 3D-printed polycaprolactone (PCL) and polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) membranes with a conventional commercial collagen membrane in terms of their abilities to facilitate guided bone regeneration (GBR). Fabricated membranes were tested for dry and wet mechanical properties. Fibroblasts and preosteoblasts were seeded into the membranes and rates and patterns of proliferation were analyzed using a kit-8 assay and by scanning electron microscopy. Osteogenic differentiation was verified by alizarin red S and alkaline phosphatase (ALP) staining. An in vivo experiment was performed using an alveolar bone defect beagle model, in which defects in three dogs were covered with different membranes. CT and histological analyses at eight weeks after surgery revealed that 3D-printed PCL/β-TCP membranes were more effective than 3D-printed PCL, and substantially better than conventional collagen membranes in terms of biocompatibility and bone regeneration and, thus, at facilitating GBR. View Full-Text
Keywords: 3D printing; animal study; collagen membrane; guided bone regeneration (GBR); membrane; polycaprolactone (PCL); β-tricalcium phosphate (β-TCP) 3D printing; animal study; collagen membrane; guided bone regeneration (GBR); membrane; polycaprolactone (PCL); β-tricalcium phosphate (β-TCP)

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shim, J.-H.; Won, J.-Y.; Park, J.-H.; Bae, J.-H.; Ahn, G.; Kim, C.-H.; Lim, D.-H.; Cho, D.-W.; Yun, W.-S.; Bae, E.-B.; Jeong, C.-M.; Huh, J.-B. Effects of 3D-Printed Polycaprolactone/β-Tricalcium Phosphate Membranes on Guided Bone Regeneration. Int. J. Mol. Sci. 2017, 18, 899.

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