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Int. J. Mol. Sci. 2017, 18(5), 1003; doi:10.3390/ijms18051003

Oral Mucositis: Melatonin Gel an Effective New Treatment

1
Department of Zoology and Entomology, Faculty of Science, Helwan University, 11795 Cairo, Egypt
2
Centro de Investigación Biomédica, Universidad de Granada, 18016 Granada, Spain
3
CIBERfes, Ibs.Granada, and UGC de Laboratorios Clínicos, Complejo Hospitalario de Granada, 18014 Granada, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Russel J. Reiter
Received: 8 March 2017 / Revised: 19 April 2017 / Accepted: 3 May 2017 / Published: 7 May 2017
(This article belongs to the Special Issue Melatonin and Its Analogues: Experimental and Clinical Aspects)
View Full-Text   |   Download PDF [940 KB, uploaded 7 May 2017]   |  

Abstract

The current treatment for cervico-facial cancer involves radio and/or chemotherapy. Unfortunately, cancer therapies can lead to local and systemic complications such as mucositis, which is the most common dose-dependent complication in the oral cavity and gastrointestinal tract. Mucositis can cause a considerably reduced quality of life in cancer patients already suffering from physical and psychological exhaustion. However, the role of melatonin in the treatment of mucositis has recently been investigated, and offers an effective alternative therapy in the prevention and/or management of radio and/or chemotherapy-induced mucositis. This review focuses on the pathobiology and management of mucositis in order to improve the quality of cancer patients’ lives. View Full-Text
Keywords: mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Abdel Moneim, A.E.; Guerra-Librero, A.; Florido, J.; Shen, Y.-Q.; Fernández-Gil, B.; Acuña-Castroviejo, D.; Escames, G. Oral Mucositis: Melatonin Gel an Effective New Treatment. Int. J. Mol. Sci. 2017, 18, 1003.

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