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Int. J. Mol. Sci. 2017, 18(4), 811; doi:10.3390/ijms18040811

Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis

1
Department of Biochemistry & Molecular Biology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan
2
Laboratory of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Vassilis G. Gorgoulis, Athanassios Kotsinas, Alexandros G. Georgakilas, Ioannis Trougakos and Aristides Eliopoulos
Received: 22 February 2017 / Revised: 8 April 2017 / Accepted: 9 April 2017 / Published: 12 April 2017
(This article belongs to the Special Issue Mechanisms Leading to Genomic Instability)
View Full-Text   |   Download PDF [832 KB, uploaded 12 April 2017]   |  

Abstract

v-Src, an oncogene found in Rous sarcoma virus, is a constitutively active variant of c-Src. Activation of Src is observed frequently in colorectal and breast cancers, and is critical in tumor progression through multiple processes. However, in some experimental conditions, v-Src causes growth suppression and apoptosis. In this review, we highlight recent progress in our understanding of cytokinesis failure and the attenuation of the tetraploidy checkpoint in v-Src-expressing cells. v-Src induces cell cycle changes—such as the accumulation of the 4N cell population—and increases the number of binucleated cells, which is accompanied by an excess number of centrosomes. Time-lapse analysis of v-Src-expressing cells showed that cytokinesis failure is caused by cleavage furrow regression. Microscopic analysis revealed that v-Src induces delocalization of cytokinesis regulators including Aurora B and Mklp1. Tetraploid cell formation is one of the causes of chromosome instability; however, tetraploid cells can be eliminated at the tetraploidy checkpoint. Interestingly, v-Src weakens the tetraploidy checkpoint by inhibiting the nuclear exclusion of the transcription coactivator YAP, which is downstream of the Hippo pathway and its nuclear exclusion is critical in the tetraploidy checkpoint. We also discuss the relationship between v-Src-induced chromosome instability and growth suppression in v-Src-induced oncogenesis. View Full-Text
Keywords: v-Src; cytokinesis; tetraploidy checkpoint; YAP; chromosome instability v-Src; cytokinesis; tetraploidy checkpoint; YAP; chromosome instability
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nakayama, Y.; Soeda, S.; Ikeuchi, M.; Kakae, K.; Yamaguchi, N. Cytokinesis Failure Leading to Chromosome Instability in v-Src-Induced Oncogenesis. Int. J. Mol. Sci. 2017, 18, 811.

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