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Int. J. Mol. Sci. 2017, 18(4), 760; doi:10.3390/ijms18040760

Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation

1
Institute of Neuropathology, University Medical Center, Robert-Koch-Straße 40, Göttingen 37075, Germany
2
Neurologic Clinic and Policlinic, University Hospital Basel, Basel 4031, Switzerland
3
Institute of Neuropathology, University Hospital Essen, Hufelandstr. 55, Essen 45122, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Christoph Kleinschnitz, Sven Meuth and Kurt A. Jellinger
Received: 25 November 2016 / Revised: 28 March 2017 / Accepted: 29 March 2017 / Published: 4 April 2017
(This article belongs to the Special Issue Advances in Multiple Sclerosis 2016)
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Abstract

Multiple sclerosis is a chronic inflammatory disease of the central nervous system, characterized by demyelination and axonal damage as well as neuronal degeneration. Since oxygen-derived free radicals are an important factor leading to tissue damage in inflammatory multiple sclerosis (MS) lesions, research on antioxidative systems is essential to identify endogenous factors which can possibly counteract oxidative damage. As an important scavenging enzyme family, peroxiredoxins (PRDXs) play a crucial role in preventing oxidative damage; however little is known about their expression and function in MS lesions. In the present study we examined the expression of PRDX2 in white matter lesions of MS patients with long-standing, chronic disease. PRDX2 expression was investigated by immunohistochemistry in the context of oxidative stress and inflammation (determined by microglia/macrophage and T cell infiltration) in ten MS autopsy cases as well as seven control autopsy cases. PRDX2 was found to be upregulated in white matter MS lesions mainly in astrocytes, and its expression level was positively correlated with the degree of inflammation and oxidative stress. Our data suggest that PRDX2 expression contributes to the resistance of astrocytes against oxidative damage. View Full-Text
Keywords: multiple sclerosis (MS); peroxiredoxin 2 (PRDX2); NAD(P)H quinone dehydrogenase 1 (NQO1); oxidative stress; inflammation multiple sclerosis (MS); peroxiredoxin 2 (PRDX2); NAD(P)H quinone dehydrogenase 1 (NQO1); oxidative stress; inflammation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Voigt, D.; Scheidt, U.; Derfuss, T.; Brück, W.; Junker, A. Expression of the Antioxidative Enzyme Peroxiredoxin 2 in Multiple Sclerosis Lesions in Relation to Inflammation. Int. J. Mol. Sci. 2017, 18, 760.

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