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Int. J. Mol. Sci. 2017, 18(4), 758; doi:10.3390/ijms18040758

The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury

Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia
Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, University of Sydney, Sydney NSW 2006, Australia
Author to whom correspondence should be addressed.
Received: 16 January 2017 / Revised: 26 February 2017 / Accepted: 27 March 2017 / Published: 3 April 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions)
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Burns are a global public health problem, accounting for an estimated 265,000 deaths annually. Inflammation is essential in supplying the growth factors, cytokines and chemokines needed to recruit T-cells and myeloid cells to the site of a burn injury for wound healing. However, major burns generate a marked pathophysiological inflammatory response through a widespread release of abundant pro-inflammatory mediators that predispose patients to a systemic inflammatory response syndrome, sepsis and multi-organ failure. Recently, there has been promising investigation into the role of γδ T-cells and Th-17 cells in the regulation and propagation of this inflammatory response. This study reviews the current literature on the post-burn immune response. View Full-Text
Keywords: burns; inflammation; systemic inflammatory response; γδ T-cells; cytokines burns; inflammation; systemic inflammatory response; γδ T-cells; cytokines

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kim, A.; Lang, T.; Xue, M.; Wijewardana, A.; Jackson, C.; Vandervord, J. The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury. Int. J. Mol. Sci. 2017, 18, 758.

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