Next Article in Journal
Melatonin Pharmacological Blood Levels Increase Total Antioxidant Capacity in Critically Ill Patients
Previous Article in Journal
A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities
Previous Article in Special Issue
Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(4), 758; doi:10.3390/ijms18040758

The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury

1
Severe Burns Unit, Royal North Shore Hospital, St Leonards NSW 2065, Australia
2
Sutton Arthritis Research Laboratory, Institute of Bone and Joint Research, University of Sydney, Sydney NSW 2006, Australia
*
Author to whom correspondence should be addressed.
Received: 16 January 2017 / Revised: 26 February 2017 / Accepted: 27 March 2017 / Published: 3 April 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions)
View Full-Text   |   Download PDF [373 KB, uploaded 7 April 2017]   |  

Abstract

Burns are a global public health problem, accounting for an estimated 265,000 deaths annually. Inflammation is essential in supplying the growth factors, cytokines and chemokines needed to recruit T-cells and myeloid cells to the site of a burn injury for wound healing. However, major burns generate a marked pathophysiological inflammatory response through a widespread release of abundant pro-inflammatory mediators that predispose patients to a systemic inflammatory response syndrome, sepsis and multi-organ failure. Recently, there has been promising investigation into the role of γδ T-cells and Th-17 cells in the regulation and propagation of this inflammatory response. This study reviews the current literature on the post-burn immune response. View Full-Text
Keywords: burns; inflammation; systemic inflammatory response; γδ T-cells; cytokines burns; inflammation; systemic inflammatory response; γδ T-cells; cytokines
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, A.; Lang, T.; Xue, M.; Wijewardana, A.; Jackson, C.; Vandervord, J. The Role of Th-17 Cells and γδ T-Cells in Modulating the Systemic Inflammatory Response to Severe Burn Injury. Int. J. Mol. Sci. 2017, 18, 758.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top