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Int. J. Mol. Sci. 2017, 18(4), 757; doi:10.3390/ijms18040757

A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities

1
School of Chemistry, Xiangtan University, Xiangtan 411105, China
2
Hunan Province Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China
3
Key Lab of Environment-Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China
4
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, China
5
Joint Surgery Department of the Second People’s Hospital of Nanning City, Guangxi Zhuang Autonomous Region, Nanning 530021, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Charles J. Malemud
Received: 22 January 2017 / Revised: 20 March 2017 / Accepted: 28 March 2017 / Published: 3 April 2017
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
View Full-Text   |   Download PDF [4558 KB, uploaded 5 April 2017]   |  

Abstract

The seeds of Strychnos nux-vomica L., as a traditional Chinese medicine, have good anti-inflammatory and analgesic activities. However, it usually leads to gastrointestinal irritation and systemic toxicity via oral administration. In the study, it was discovered that a novel gel transdermal delivery system contained brucine, the main effective component extracted from Strychnos nux-vomica. Results showed that the brucine gel system inhibited arthritis symptoms and the proliferation of the synoviocytes in the rat adjuvant arthritis model, which indicated its curative effect for rheumatoid arthritis. Meanwhile, it significantly relieved the xylene-induced ear edema in the mouse ear swelling test, which manifested its anti-inflammatory property. Moreover, the brucine gel eased the pain of paw formalin injection in the formalin test, which demonstrated its analgesic effects. In addition, the brucine significantly inhibited lipopolysaccharide (LPS)-induced Prostaglandin E2 (PGE2) production without affecting the viability of cell in vitro anti-inflammatory test, which proved that its anti-inflammatory and analgesic actions were related to inhibition of prostaglandin synthesis. It is suggested that the brucine gel is a promising vehicle for transdermal delivery on the treatment of inflammatory disease. View Full-Text
Keywords: brucine gel; anti-inflammatory; analgesic activities; transdermal delivery brucine gel; anti-inflammatory; analgesic activities; transdermal delivery
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Wu, P.; Liang, Q.; Feng, P.; Li, C.; Yang, C.; Liang, H.; Tang, H.; Shuai, C. A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities. Int. J. Mol. Sci. 2017, 18, 757.

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