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Int. J. Mol. Sci. 2017, 18(3), 634; doi:10.3390/ijms18030634

Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways

Department of Molecular and Cellular Genetics, Université de Strasbourg, CNRS, GMGM UMR 7156, F-67000 Strasbourg, France
Present address: EA 2106, Biomolécules et Biotechnologies Végétales, Université François Rabelais de Tours, UFR Sciences et Techniques, Parc de Grandmont, 37200 Tours, France.
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Academic Editor: Gian-Pietro Di Sansebastiano
Received: 19 January 2017 / Revised: 2 March 2017 / Accepted: 6 March 2017 / Published: 15 March 2017
(This article belongs to the Special Issue Unconventional Proteins and Membranes Traffic)
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Abstract

Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids between the different compartments of eukaryotic cells. They act by recruiting and/or activating effector proteins and thus are involved in regulating various cellular functions, such as vesicular budding, membrane fusion and cytoskeleton dynamics. Although detected in small concentrations in membranes, their role is essential to cell function, since imbalance in their concentrations is a hallmark of many cancers. Their synthesis involves phosphorylating/dephosphorylating positions D3, D4 and/or D5 of their inositol ring by specific lipid kinases and phosphatases. This process is tightly regulated and specific to the different intracellular membranes. Most enzymes involved in phosphoinositide synthesis are conserved between yeast and human, and their loss of function leads to severe diseases (cancer, myopathy, neuropathy and ciliopathy). View Full-Text
Keywords: lipids; membrane trafficking; vesicles; phosphoinositides; phosphatase; kinase lipids; membrane trafficking; vesicles; phosphoinositides; phosphatase; kinase
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MDPI and ACS Style

De Craene, J.-O.; Bertazzi, D.L.; Bär, S.; Friant, S. Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways. Int. J. Mol. Sci. 2017, 18, 634.

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