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Int. J. Mol. Sci. 2017, 18(3), 630; doi:10.3390/ijms18030630

A Review on Ubiquitination of Neurotrophin Receptors: Facts and Perspectives

1
Department of Cell Biology and Pathology, Institute of Neuroscience Castile & Leon, University of Salamanca, 37007 Salamanca, Spain
2
Institute of Biomedical Research of Salamanca, 37007 Salamanca, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Nobuhiro Nakamura
Received: 9 February 2017 / Revised: 7 March 2017 / Accepted: 10 March 2017 / Published: 14 March 2017
(This article belongs to the Special Issue Ubiquitin System)
View Full-Text   |   Download PDF [984 KB, uploaded 14 March 2017]   |  

Abstract

Ubiquitination is a reversible post-translational modification involved in a plethora of different physiological functions. Among the substrates that are ubiquitinated, neurotrophin receptors (TrkA, TrkB, TrkC, and p75NTR) have been studied recently. TrkA is the most studied receptor in terms of its ubiquitination, and different E3 ubiquitin ligases and deubiquitinases have been implicated in its ubiquitination, whereas not much is known about the other neurotrophin receptors aside from their ubiquitination. Additional studies are needed that focus on the ubiquitination of TrkB, TrkC, and p75NTR in order to further understand the role of ubiquitination in their physiological and pathological functions. Here we review what is currently known regarding the ubiquitination of neurotrophin receptors and its physiological and pathological relevance. View Full-Text
Keywords: deubiquitination; neurotrophins; p75NTR; Trk receptors; ubiquitination deubiquitination; neurotrophins; p75NTR; Trk receptors; ubiquitination
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sánchez-Sánchez, J.; Arévalo, J.C. A Review on Ubiquitination of Neurotrophin Receptors: Facts and Perspectives. Int. J. Mol. Sci. 2017, 18, 630.

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