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Int. J. Mol. Sci. 2017, 18(3), 629; doi:10.3390/ijms18030629

Treatment with 17β-Estradiol Reduced Body Weight and the Risk of Cardiovascular Disease in a High-Fat Diet-Induced Animal Model of Obesity

1
The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, B24 Yinquan South Road, Qingyuan 511518, China
2
Graduate Institute of Basic Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
3
Graduate Institute of Chinese Medical Science, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
4
Department of Health and Nutrition Biotechnology, Asia University, 500 Lioufeng Road, Taichung 41354, Taiwan
5
Department of Urology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, B24 Yinquan South Road, Qingyuan 511518, China
6
Department of Pathology, Changhua Christian Hospital, 135 Nanxiao Street, Changhua 50006, Taiwan
7
Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, 79-9 Sha-Luen Hu, Hou-Loung Town, Miaoli 35664, Taiwan
8
Department of Hospital and Health Care Administration, China Nan University of Pharmacy & Science, 60, Section 1, Erren Road, Rende District, Tainan 71710, Taiwan
9
Department of Nursing, Mei Ho University, 23 Pingguang Road, Pingtung 91202, Taiwan
10
Division of Cardiology, China Medical University Hospital, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
11
Department of Emergency Medicine, China Medical University Hospital, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
12
Department of Biotechnology, Bharathiar University, Coimbatore 641046, India
13
School of Medicine, College of Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Charles Brennan
Received: 5 January 2017 / Revised: 25 February 2017 / Accepted: 8 March 2017 / Published: 14 March 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [2039 KB, uploaded 14 March 2017]   |  

Abstract

Estrogen receptor α (ERα) and estrogen receptor β (ERβ) play important roles in cardiovascular disease (CVD) prevention. Recently, these estrogen receptors were reconsidered as an important treatment target of obesity leading to CVD. In this study, 17β-estradiol (17β-E) replacement therapy applied to high-fat diet-induced obese C57B male mice and ovariectomized (OVX) rats were evaluated, and the protective effects against high-fat diet-induced obesity were assessed in C57B mouse hearts. The results showed that 17β-E treatment activated both ERα and ERβ, and ERβ levels increased in a dose-dependent manner in high-fat diet C57B mouse cardiomyocytes following 17β-E treatment. Notably, an almost 16% reduction in body weight was observed in the 17β-E-treated (12 μg/kg/day for 60 days) high-fat diet-induced obese C57B male mice. These results suggested that 17β-E supplements may reduce CVD risk due to obesity. View Full-Text
Keywords: estrogen receptor α; estrogen receptor β; 17β-estradiol; heart protection estrogen receptor α; estrogen receptor β; 17β-estradiol; heart protection
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Ting, W.-J.; Huang, C.-Y.; Jiang, C.-H.; Lin, Y.-M.; Chung, L.-C.; Shen, C.-Y.; Pai, P.; Lin, K.-H.; Viswanadha, V.P.; Liao, S.-C. Treatment with 17β-Estradiol Reduced Body Weight and the Risk of Cardiovascular Disease in a High-Fat Diet-Induced Animal Model of Obesity. Int. J. Mol. Sci. 2017, 18, 629.

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