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Int. J. Mol. Sci. 2017, 18(3), 518; doi:10.3390/ijms18030518

Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice

1
Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA, Wanju-gun 55365, Korea
2
Department of Biochemistry, School of Medicine, Dongguk University, Gyeongju 780-714, Korea
3
Graduate School of Integrated Bioindustry, Sejong University, Seoul 05006, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Charles Brennan
Received: 19 December 2016 / Revised: 6 February 2017 / Accepted: 15 February 2017 / Published: 28 February 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [1702 KB, uploaded 28 February 2017]   |  

Abstract

Despite the increasing interest in insect-based bioactive products, the biological activities of these products are rarely studied adequately. Larvae of Tenebrio molitor, the yellow mealworm, have been eaten as a traditional food and provide many health benefits. Therefore, we hypothesized that T. molitor larvae might influence adipogenesis and obesity-related disorders. In the present study, we investigated the anti-adipogenic and antiobesity effects of T. molitor larvae in vitro and in vivo. The lipid accumulation and triglyceride content in mature adipocytes was reduced significantly (up to 90%) upon exposure to an ethanol extract of T. molitor larvae, without a reduction in cell viability. Exposure also resulted in key adipogenic and lipogenic transcription factors. Additionally, in adipogenic differentiation medium the extract induced phosphorylation of adenosine monophosphate (AMP)-activated protein kinase and mitogen-activated protein kinases. Daily oral administration of T. molitor larvae powder to obese mice fed high-fat diet attenuated body weight gain. We also found that the powder efficiently reduced hepatic steatosis as well as aspartate and alanine transaminase enzyme levels in mice fed a high-fat diet. Our results suggest that T. molitor larvae extract has an antiobesity effect when administered as a food supplement and has potential as a therapeutic agent for obesity. View Full-Text
Keywords: Tenebrio molitor larvae; diet-induced obesity; 3T3-L1; adipogenesis; hepatic steatosis Tenebrio molitor larvae; diet-induced obesity; 3T3-L1; adipogenesis; hepatic steatosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Seo, M.; Goo, T.-W.; Chung, M.Y.; Baek, M.; Hwang, J.-S.; Kim, M.-A.; Yun, E.-Y. Tenebrio molitor Larvae Inhibit Adipogenesis through AMPK and MAPKs Signaling in 3T3-L1 Adipocytes and Obesity in High-Fat Diet-Induced Obese Mice. Int. J. Mol. Sci. 2017, 18, 518.

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