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Int. J. Mol. Sci. 2017, 18(3), 476; doi:10.3390/ijms18030476

Pro-Resolving Molecules—New Approaches to Treat Sepsis?

1
Department of Internal Medicine I, Regensburg University Hospital, 93042 Regensburg, Germany
2
Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, 93042 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Marica Bakovic
Received: 9 November 2016 / Revised: 15 February 2017 / Accepted: 15 February 2017 / Published: 23 February 2017
(This article belongs to the Special Issue Nutrigenomics of Risk Factors for Disease)
View Full-Text   |   Download PDF [3069 KB, uploaded 23 February 2017]   |  

Abstract

Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches to down-modulate mediators relevant for the onset and duration of inflammation are successful in some chronic diseases, while all of them have failed in sepsis patients. Inflammation and immune suppression characterize sepsis, indicating that anti-inflammatory strategies alone are inappropriate for its therapy. Heme oxygenase 1 is a sensitive marker for oxidative stress and is upregulated in inflammation. Carbon monoxide, which is produced by this enzyme, initiates multiple anti-inflammatory and pro-resolving activities with higher production of omega-3 fatty acid-derived lipid metabolites being one of its protective actions. Pro-resolving lipids named maresins, resolvins and protectins originate from the omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid while lipoxins are derived from arachidonic acid. These endogenously produced lipids do not simply limit inflammation but actively contribute to its resolution, and thus provide an opportunity to combat chronic inflammatory diseases and eventually sepsis. View Full-Text
Keywords: carbon monoxide; resolvin; cyclooxygenase; lipoxygenase carbon monoxide; resolvin; cyclooxygenase; lipoxygenase
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Buechler, C.; Pohl, R.; Aslanidis, C. Pro-Resolving Molecules—New Approaches to Treat Sepsis? Int. J. Mol. Sci. 2017, 18, 476.

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