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Int. J. Mol. Sci. 2017, 18(2), 442; doi:10.3390/ijms18020442

Essential Roles of E3 Ubiquitin Ligases in p53 Regulation

Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA
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Author to whom correspondence should be addressed.
Academic Editor: Tomoo Iwakuma
Received: 19 November 2016 / Revised: 10 February 2017 / Accepted: 11 February 2017 / Published: 17 February 2017
(This article belongs to the Special Issue Emerging Non-Canonical Functions and Regulation of p53)
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Abstract

The ubiquitination pathway and proteasomal degradation machinery dominantly regulate p53 tumor suppressor protein stability, localization, and functions in both normal and cancerous cells. Selective E3 ubiquitin ligases dominantly regulate protein levels and activities of p53 in a large range of physiological conditions and in response to cellular changes induced by exogenous and endogenous stresses. The regulation of p53’s functions by E3 ubiquitin ligases is a complex process that can lead to positive or negative regulation of p53 protein in a context- and cell type-dependent manner. Accessory proteins bind and modulate E3 ubiquitin ligases, adding yet another layer of regulatory control for p53 and its downstream functions. This review provides a comprehensive understanding of p53 regulation by selective E3 ubiquitin ligases and their potential to be considered as a new class of biomarkers and therapeutic targets in diverse types of cancers. View Full-Text
Keywords: p53 tumor suppressor protein; E3 ubiquitin ligases; tumor; cancer therapy; apoptosis p53 tumor suppressor protein; E3 ubiquitin ligases; tumor; cancer therapy; apoptosis
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Sane, S.; Rezvani, K. Essential Roles of E3 Ubiquitin Ligases in p53 Regulation. Int. J. Mol. Sci. 2017, 18, 442.

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