Next Article in Journal
Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group
Previous Article in Journal
Big Data Analytics for Genomic Medicine
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2017, 18(2), 416; doi:10.3390/ijms18020416

The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases

1
Departamento de Farmacología y Fisiología, Facultad de Ciencias de la Salud y del Deporte, Huesca E-22002, Spain
2
Instituto de Investigación Sanitaria de Aragón, Universidad de Zaragoza, Zaragoza E-50009, Spain
3
Instituto Agroalimentario de Aragón, Centro de Investigación y Tecnología Agroalimentaria, Universidad de Zaragoza, Zaragoza E-50013, Spain
4
Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid E-28029, Spain
5
Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Zaragoza E-50013, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 15 December 2016 / Revised: 31 January 2017 / Accepted: 10 February 2017 / Published: 15 February 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
View Full-Text   |   Download PDF [576 KB, uploaded 15 February 2017]   |  

Abstract

Low levels of paraoxonase 1 (PON1) have been associated with the development of several pathological conditions, whereas high levels have been shown to be anti-atherosclerotic in mouse models. These findings suggest that PON1 could be a good surrogate biomarker. The other members of the family, namely PON2 and PON3, the role of which has been much less studied, deserve more attention. This paper provides a systematic review of current evidence concerning dietary supplements in that regard. Preliminary studies indicate that the response to dietary supplements may have a nutrigenetic aspect that will need to be considered in large population studies or in clinical trials. A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized and Aronia melanocarpa one of the most active. Flavonoids are found in the composition of all active extracts, with catechins and genistein being the most promising agents for increasing PON1 activity. However, some caveats regarding the dose, length of treatment, bioavailability, and stability of these compounds in formulations still need to be addressed. Once these issues have been resolved, these compounds could be included as nutraceuticals and functional foods capable of increasing PON1 activity, thereby helping with the long-term prevention of atherosclerosis and other chronic ailments. View Full-Text
Keywords: paraoxonase 1; paraoxonase 2; catechins; genistein; plant extracts; atherosclerosis paraoxonase 1; paraoxonase 2; catechins; genistein; plant extracts; atherosclerosis
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lou-Bonafonte, J.M.; Gabás-Rivera, C.; Navarro, M.A.; Osada, J. The Search for Dietary Supplements to Elevate or Activate Circulating Paraoxonases. Int. J. Mol. Sci. 2017, 18, 416.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top