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Int. J. Mol. Sci. 2017, 18(2), 411; doi:10.3390/ijms18020411

Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases

1
Department of Neuroplasticity, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
2
Bio-X Institutes, Key Laboratory for the Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
3
Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan
4
Department of Neuroplasticity, Institute of Pathogenesis and Disease Prevention, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan
5
Department of Biological Sciences for Intractable Neurological Diseases, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Received: 26 December 2016 / Revised: 1 February 2017 / Accepted: 9 February 2017 / Published: 15 February 2017
(This article belongs to the Special Issue Pre-mRNA Splicing 2016)
View Full-Text   |   Download PDF [841 KB, uploaded 15 February 2017]   |  

Abstract

We previously reported that various mRNAs were associated with postsynaptic density (PSD) purified from rat forebrain. Among the thousands of PSD-associated mRNAs, we highlight the biology of the general transcription factor II-I (Gtf2i) mRNA, focusing on the significance of its versatile splicing for targeting its own mRNA into dendrites, regulation of translation, and the effects of Gtf2i expression level as well as its relationship with neuropsychiatric disorders. View Full-Text
Keywords: postsynaptic density; synapse; local protein synthesis; transcription factor; neuropsychiatric disorders; 5′UTR; alternative splicing; synaptic plasticity postsynaptic density; synapse; local protein synthesis; transcription factor; neuropsychiatric disorders; 5′UTR; alternative splicing; synaptic plasticity
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MDPI and ACS Style

Shirai, Y.; Li, W.; Suzuki, T. Role of Splice Variants of Gtf2i, a Transcription Factor Localizing at Postsynaptic Sites, and Its Relation to Neuropsychiatric Diseases. Int. J. Mol. Sci. 2017, 18, 411.

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