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Int. J. Mol. Sci. 2017, 18(2), 407; doi:10.3390/ijms18020407

Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development

1
Laboratorio de microRNAs, Unidad Académica de Ciencias Biológicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Zacatecas 98066, Mexico
2
Doctorado en Ciencias Básicas, Universidad Autónoma de Zacateacs, Av. Preparatoria S/N, Campus II, Zacatecas 98066, Mexico
3
School of Life Sciences, Gibbert Hill Campus, University of Warwick, Coventry CV47AL, UK
4
Doctorado en Ciencias Básicas en la Especialidad en Farmacología Médica y Molecular de la Unidad Académica de Medicina Humana y Ciencias de la Salud de la Universidad Autónoma de Zacateacas, Campus Siglo XXI, Kilómetro 6, Ejido la Escondida, Zacatecas CP 98160, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 10 January 2017 / Revised: 3 February 2017 / Accepted: 8 February 2017 / Published: 14 February 2017
(This article belongs to the Special Issue microRNA Regulation 2017)
View Full-Text   |   Download PDF [4351 KB, uploaded 14 February 2017]   |  

Abstract

Aberrant miRNA expression is well recognized as a cancer hallmark, nevertheless miRNA function and expression does not always correlate in patients tissues and cell lines studies. In addition to this issue, miRNA strand usage conduces to increased cell signaling pathways modulation diversifying cellular processes regulation. In cervical cancer, 20 miRNA families are involved in carcinogenesis induction and development to this moment. These families have 5p and 3p strands with different nucleotide (nt) chain sizes. In general, mature 5p strands are larger: two miRNAs of 24 nt, 24 miRNAs of 23 nt, 35 miRNAs of 22 nt and three miRNAs of 21 nt. On the other hand, the 3p strands lengths observed are: seven miRNAs of 23 nt, 50 miRNAs of 22 nt, six miRNAs of 21 nt and four miRNAs of 20 nt. Based on the analysis of the 20 miRNA families associated with cervical cancer, 67 3p strands and 65 5p strands are selected suggesting selectivity and specificity mechanisms regulating cell processes like proliferation, apoptosis, migration, invasion, metabolism and Warburg effect. The insight reviewed here could be used in the miRNA based therapy, diagnosis and prognosis approaches. View Full-Text
Keywords: miRNA families; strand 5p; strand 3p; cervical cancer miRNA families; strand 5p; strand 3p; cervical cancer
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MDPI and ACS Style

Granados-López, A.J.; Ruiz-Carrillo, J.L.; Servín-González, L.S.; Martínez-Rodríguez, J.L.; Reyes-Estrada, C.A.; Gutiérrez-Hernández, R.; López, J.A. Use of Mature miRNA Strand Selection in miRNAs Families in Cervical Cancer Development. Int. J. Mol. Sci. 2017, 18, 407.

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