Int. J. Mol. Sci. 2017, 18(2), 366; doi:10.3390/ijms18020366
Splicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs
Department of Laboratory Medicine, Lund university, 223 62 Lund, Sweden
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Authors to whom correspondence should be addressed.
Academic Editor: Akila Mayeda
Received: 3 January 2017 / Revised: 29 January 2017 / Accepted: 3 February 2017 / Published: 9 February 2017
(This article belongs to the Special Issue Pre-mRNA Splicing 2016)
Abstract
The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early gene expression program to the late requires a promoter switch, a polyadenylation signal switch and a shift in alternative splicing. A number of cis-acting RNA elements on the HPV16 mRNAs and cellular and viral factors interacting with these elements are involved in the control of HPV16 gene expression. This review summarizes our knowledge of HPV16 cis-acting RNA elements and cellular and viral trans-acting factors that regulate HPV16 gene expression at the level of splicing and polyadenylation. View Full-TextKeywords:
human papillomavirus; HPV16; splicing; polyadenylation; hnRNP; SR-protein
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Wu, C.; Kajitani, N.; Schwartz, S. Splicing and Polyadenylation of Human Papillomavirus Type 16 mRNAs. Int. J. Mol. Sci. 2017, 18, 366.
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