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Int. J. Mol. Sci. 2017, 18(2), 281; doi:10.3390/ijms18020281

Radiation-Induced Organizing Pneumonia: A Characteristic Disease that Requires Symptom-Oriented Management

Department of Radiation Oncology, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Susanna Esposito
Received: 30 November 2016 / Revised: 16 January 2017 / Accepted: 24 January 2017 / Published: 27 January 2017
(This article belongs to the Special Issue Pneumonia: Pathogenesis, Diagnostics, Therapeutics, and Prevention)
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Abstract

Radiation-induced organizing pneumonia (RIOP) is an inflammatory lung disease that is occasionally observed after irradiation to the breast. It is a type of secondary organizing pneumonia that is characterized by infiltrates outside the irradiated volume that are sometimes migratory. Corticosteroids work acutely, but relapse of pneumonia is often experienced. Management of RIOP should simply be symptom-oriented, and the use of corticosteroids should be limited to severe symptoms from the perspective not only of cost-effectiveness but also of cancer treatment. Once steroid therapy is started, it takes a long time to stop it due to frequent relapses. We review RIOP from the perspective of its diagnosis, epidemiology, molecular pathogenesis, and patient management. View Full-Text
Keywords: organizing pneumonia; bronchiolitis obliterans organizing pneumonia; breast cancer; corticosteroid treatment; radiation-induced organizing pneumonia organizing pneumonia; bronchiolitis obliterans organizing pneumonia; breast cancer; corticosteroid treatment; radiation-induced organizing pneumonia
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Otani, K.; Seo, Y.; Ogawa, K. Radiation-Induced Organizing Pneumonia: A Characteristic Disease that Requires Symptom-Oriented Management. Int. J. Mol. Sci. 2017, 18, 281.

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