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Int. J. Mol. Sci. 2017, 18(2), 260; doi:10.3390/ijms18020260

Review: Receptor Targeted Nuclear Imaging of Breast Cancer

Department of Radiology & Nuclear medicine, Erasmus MC, Wytemaweg 80, 3015CN Rotterdam, The Netherlands
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Author to whom correspondence should be addressed.
Academic Editors: Jamal Zweit and Sundaresan Gobalakrishnan
Received: 1 October 2016 / Revised: 17 January 2017 / Accepted: 20 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue Cancer Molecular Imaging in the Era of Precision Medicine)
View Full-Text   |   Download PDF [3640 KB, uploaded 26 January 2017]   |  

Abstract

Receptor targeted nuclear imaging directed against molecular markers overexpressed on breast cancer (BC) cells offers a sensitive and specific method for BC imaging. Currently, a few targets such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), somatostatin receptor (SSTR), and the gastrin releasing peptide receptor (GRPR) are being investigated for this purpose. Expression of these targets is BC subtype dependent and information that can be gained from lesion visualization is dependent on the target; ER-targeting radiotracers, e.g., can be used to monitor response to anti-estrogen treatment. Here we give an overview of the studies currently under investigation for receptor targeted nuclear imaging of BC. Main findings of imaging studies are summarized and (potential) purposes of lesion visualization by targeting these molecular markers are discussed. Since BC is a very heterogeneous disease and molecular target expression can vary per subtype, but also during disease progression or under influence of treatment, radiotracers for selected imaging purposes should be chosen carefully. View Full-Text
Keywords: breast cancer; receptor targeted nuclear imaging; SPECT; PET; GRPR; SSTR; ER; PR; HER2 breast cancer; receptor targeted nuclear imaging; SPECT; PET; GRPR; SSTR; ER; PR; HER2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dalm, S.U.; Verzijlbergen, J.F.; De Jong, M. Review: Receptor Targeted Nuclear Imaging of Breast Cancer. Int. J. Mol. Sci. 2017, 18, 260.

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