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Int. J. Mol. Sci. 2017, 18(2), 261; doi:10.3390/ijms18020261

Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer

1
Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan
2
Corporate R&D Headquarters, Konica Minolta, Inc., Hino-shi, Tokyo 191-8511, Japan
3
Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Carsten Stephan
Received: 28 December 2016 / Revised: 17 January 2017 / Accepted: 19 January 2017 / Published: 26 January 2017
(This article belongs to the Special Issue Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer)
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Abstract

Wisteria floribunda agglutinin (WFA) preferably binds to LacdiNAc glycans, and its reactivity is associated with tumor progression. The aim of this study to examine whether the serum LacdiNAc carrying prostate-specific antigen–glycosylation isomer (PSA-Gi) and WFA-reactivity of tumor tissue can be applied as a diagnostic and prognostic marker of prostate cancer (PCa). Between 2007 and 2016, serum PSA-Gi levels before prostate biopsy (Pbx) were measured in 184 biopsy-proven benign prostatic hyperplasia patients and 244 PCa patients using an automated lectin-antibody immunoassay. WFA-reactivity on tumor was analyzed in 260 radical prostatectomy (RP) patients. Diagnostic and prognostic performance of serum PSA-Gi was evaluated using area under the receiver-operator characteristic curve (AUC). Prognostic performance of WFA-reactivity on tumor was evaluated via Cox proportional hazards regression analysis and nomogram. The AUC of serum PSA-Gi detecting PCa and predicting Pbx Grade Group (GG) 3 and GG ≥ 3 after RP was much higher than those of conventional PSA. Multivariate analysis showed that WFA-reactivity on prostate tumor was an independent risk factor of PSA recurrence. The nomogram was a strong model for predicting PSA-free survival provability with a c-index ≥0.7. Serum PSA-Gi levels and WFA-reactivity on prostate tumor may be a novel diagnostic and pre- and post-operative prognostic biomarkers of PCa, respectively. View Full-Text
Keywords: prostate-specific antigen; N-glycan; LacdiNAc; Wisteria floribunda agglutinin (WFA) lectin; biomarker prostate-specific antigen; N-glycan; LacdiNAc; Wisteria floribunda agglutinin (WFA) lectin; biomarker
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Hagiwara, K.; Tobisawa, Y.; Kaya, T.; Kaneko, T.; Hatakeyama, S.; Mori, K.; Hashimoto, Y.; Koie, T.; Suda, Y.; Ohyama, C.; Yoneyama, T. Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer. Int. J. Mol. Sci. 2017, 18, 261.

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