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Int. J. Mol. Sci. 2017, 18(12), 2731; https://doi.org/10.3390/ijms18122731

Preclinical Imaging for the Study of Mouse Models of Thyroid Cancer

1
Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, 80131 Napoli, Italy
2
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche—IBB, CNR, 80145 Napoli, Italy
3
CEINGE Biotecnologie Avanzate s.c.ar.l., 80131 Napoli, Italy
4
IRCCS S.D.N., 80134 Napoli, Italy
5
Dipartimento di Scienze Motorie e del Benessere, Università di Napoli Parthenope, 80133 Napoli, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 14 November 2017 / Revised: 5 December 2017 / Accepted: 8 December 2017 / Published: 16 December 2017
(This article belongs to the Special Issue Cell and Molecular Biology of Thyroid Disorders)
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Abstract

Thyroid cancer, which represents the most common tumors among endocrine malignancies, comprises a wide range of neoplasms with different clinical aggressiveness. One of the most important challenges in research is to identify mouse models that most closely resemble human pathology; other goals include finding a way to detect markers of disease that common to humans and mice and to identify the most appropriate and least invasive therapeutic strategies for specific tumor types. Preclinical thyroid imaging includes a wide range of techniques that allow for morphological and functional characterization of thyroid disease as well as targeting and in most cases, this imaging allows quantitative analysis of the molecular pattern of the thyroid cancer. The aim of this review paper is to provide an overview of all of the imaging techniques used to date both for diagnosis and theranostic purposes in mouse models of thyroid cancer. View Full-Text
Keywords: thyroid cancer; preclinical imaging; ultrasound; nuclear medicine; theranostic; mouse models thyroid cancer; preclinical imaging; ultrasound; nuclear medicine; theranostic; mouse models
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Greco, A.; Auletta, L.; Orlandella, F.M.; Iervolino, P.L.C.; Klain, M.; Salvatore, G.; Mancini, M. Preclinical Imaging for the Study of Mouse Models of Thyroid Cancer. Int. J. Mol. Sci. 2017, 18, 2731.

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