Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis
AbstractMyocarditis is an inflammatory disease of the myocardium that causes cardiogenic shock and death. However, endomyocardial biopsy that is, the gold standard for a diagnosis is limited. Apurinic/apyrimidinic endonuclease 1/redox effector factor-1 (APE1/Ref-1) is a multifunctional protein, which is involved in DNA-based excision repair pathway, and in redox signaling, its changes are observed in various cardiovascular diseases including hypertension and coronary artery disease. We analyzed serum APE1/Ref-1 in experimental murine myocarditis. To induce myocarditis, coxsackievirus B3 was injected intraperitoneally to BALB/c mice. The serum APE1/Ref-1, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and troponin I were measured. The histology and virus titers measurements were performed. The troponin I and inflammation were significantly elevated at day 3, peaked to day 7 and decreased at day 10. The NT-proBNP and virus titers were significantly peaked at day 3, and dropped at day 7 and 10. The serum APE1/Ref-1 was gradually raised and its elevation is still maintained until a later time, namely day 10. Also, its level was positively correlated with myocardial inflammation, reflecting severity of myocardial injury. We suggest that serum APE1/Ref-1 can be used to assess for myocardial injury in viral myocarditis without endomyocardial biopsy. View Full-Text
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Jin, S.-A.; Lim, B.-K.; Seo, H.J.; Kim, S.K.; Ahn, K.T.; Jeon, B.H.; Jeong, J.-O. Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis. Int. J. Mol. Sci. 2017, 18, 2664.
Jin S-A, Lim B-K, Seo HJ, Kim SK, Ahn KT, Jeon BH, Jeong J-O. Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis. International Journal of Molecular Sciences. 2017; 18(12):2664.Chicago/Turabian Style
Jin, Seon-Ah; Lim, Byung-Kwan; Seo, Hee J.; Kim, Sun K.; Ahn, Kye T.; Jeon, Byeong H.; Jeong, Jin-Ok. 2017. "Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis." Int. J. Mol. Sci. 18, no. 12: 2664.
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