Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells
AbstractOrostachys japonicus A. Berger (), known as Wa-song in Korea, has been reported to exert various biological effects, such as anti-tumor, anti-oxidant, and anti-febrile effects. However, the anti-angiogenic effects of O. japonicus extracts remain to be investigated. In the present study, we demonstrated the anti-angiogenic effects of bioconverted O. japonicus extract (BOE) in Ms-1 mouse endothelial cells and compared them with the bioactivities of O. japonicus extract (OE). BOE, but not OE, were found to exert anti-angiogenic effects, including inhibition of cell migration, cell adhesion, tube formation of Ms-1 cells, and blood vessel formation of matrigel plug assay in vivo. Furthermore, protein levels of phosphorylated Src kinase were lower in BOE-treated cells than in OE-treated cells. Treatment with OE or BOE did not influence cell viability during the experimental period. Bioconverted extract of O. japonicus have anti-angiogenic effects in vitro and vivo, but non-bioconverted extract do not. We suggest that these observed anti-angiogenic effects are caused by the changes in the composition of bioactive compounds in the extracts as a result of biological conversion. View Full-Text
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Lee, S.G.; Kim, J.S.; Lee, H.-S.; Lim, Y.-M.; So, J.-H.; Hahn, D.; Ha, Y.S.; Nam, J.-O. Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells. Int. J. Mol. Sci. 2017, 18, 2615.
Lee SG, Kim JS, Lee H-S, Lim Y-M, So J-H, Hahn D, Ha YS, Nam J-O. Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells. International Journal of Molecular Sciences. 2017; 18(12):2615.Chicago/Turabian Style
Lee, Seul G.; Kim, Jin S.; Lee, Han-Saem; Lim, Yu-Mi; So, Jai-Hyun; Hahn, Dongyup; Ha, Yu S.; Nam, Ju-Ock. 2017. "Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells." Int. J. Mol. Sci. 18, no. 12: 2615.
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