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Int. J. Mol. Sci. 2017, 18(12), 2615; https://doi.org/10.3390/ijms18122615

Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells

1
Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
2
National Development Institute of Korean Medicine, 94, Hwarang-ro, Gyeongsan, Gyeongsangbuk-do 712-260, Korea
3
Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41404, Korea
4
Department of Bio Industrial Machinery Engineering, Kyungpook National University, Daegu 41566, Korea
*
Authors to whom correspondence should be addressed.
Received: 23 October 2017 / Revised: 20 November 2017 / Accepted: 30 November 2017 / Published: 5 December 2017
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Orostachys japonicus A. Berger (), known as Wa-song in Korea, has been reported to exert various biological effects, such as anti-tumor, anti-oxidant, and anti-febrile effects. However, the anti-angiogenic effects of O. japonicus extracts remain to be investigated. In the present study, we demonstrated the anti-angiogenic effects of bioconverted O. japonicus extract (BOE) in Ms-1 mouse endothelial cells and compared them with the bioactivities of O. japonicus extract (OE). BOE, but not OE, were found to exert anti-angiogenic effects, including inhibition of cell migration, cell adhesion, tube formation of Ms-1 cells, and blood vessel formation of matrigel plug assay in vivo. Furthermore, protein levels of phosphorylated Src kinase were lower in BOE-treated cells than in OE-treated cells. Treatment with OE or BOE did not influence cell viability during the experimental period. Bioconverted extract of O. japonicus have anti-angiogenic effects in vitro and vivo, but non-bioconverted extract do not. We suggest that these observed anti-angiogenic effects are caused by the changes in the composition of bioactive compounds in the extracts as a result of biological conversion. View Full-Text
Keywords: anti-angiogenic; bioconversion; Ms-1 endothelial cells; Orostachys japonicus A. Berger; Wa-song anti-angiogenic; bioconversion; Ms-1 endothelial cells; Orostachys japonicus A. Berger; Wa-song
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Lee, S.G.; Kim, J.S.; Lee, H.-S.; Lim, Y.-M.; So, J.-H.; Hahn, D.; Ha, Y.S.; Nam, J.-O. Bioconverted Orostachys japonicas Extracts Suppress Angiogenic Activity of Ms-1 Endothelial Cells. Int. J. Mol. Sci. 2017, 18, 2615.

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