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Int. J. Mol. Sci. 2017, 18(11), 2243; doi:10.3390/ijms18112243

Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced Premature Aging

Department of Preclinical Research and Development, BioChron LLC, Worcester, MA 01605, USA
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 13 October 2017 / Accepted: 22 October 2017 / Published: 26 October 2017
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Circadian Rhythms)
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Chronic high caloric intake (HCI) is a risk factor for multiple major human disorders, from diabetes to neurodegeneration. Mounting evidence suggests a significant contribution of circadian misalignment and sleep alterations to this phenomenon. An inverse temporal relationship between sleep, activity, food intake, and clock mechanisms in nocturnal and diurnal animals suggests that a search for effective therapeutic approaches can benefit from the use of diurnal animal models. Here, we show that, similar to normal aging, HCI leads to the reduction in daily amplitude of expression for core clock genes, a decline in sleep duration, an increase in scoliosis, and anxiety-like behavior. A remarkable decline in adult neurogenesis in 1-year old HCI animals, amounting to only 21% of that in age-matched Control, exceeds age-dependent decline observed in normal 3-year old zebrafish. This is associated with misalignment or reduced amplitude of daily patterns for principal cell cycle regulators, cyclins A and B, and p20, in brain tissue. Together, these data establish HCI in zebrafish as a model for metabolically induced premature aging of sleep, circadian functions, and adult neurogenesis, allowing for a high throughput approach to mechanistic studies and drug trials in a diurnal vertebrate. View Full-Text
Keywords: premature aging; circadian; neurogenesis; sleep; high caloric intake; cell cycle; scoliosis; anxiety; diurnal vertebrate premature aging; circadian; neurogenesis; sleep; high caloric intake; cell cycle; scoliosis; anxiety; diurnal vertebrate

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Stankiewicz, A.J.; McGowan, E.M.; Yu, L.; Zhdanova, I.V. Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced Premature Aging. Int. J. Mol. Sci. 2017, 18, 2243.

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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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