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Int. J. Mol. Sci. 2017, 18(10), 2182; doi:10.3390/ijms18102182

Stem Cells as Potential Candidates for Psoriasis Cell-Replacement Therapy

1
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland
2
Department of Rheumatology, Municipal Hospital in Olsztyn, 10-900 Olsztyn, Poland
3
Department of Neurology and Neurosurgery, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland
4
Foundation for Nerve Cell Regeneration, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland
5
Department of Pathophysiology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland
6
Laboratory for Regenerative Medicine, Faculty of Medicine, University of Warmia and Mazury, 10-900 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 14 October 2017 / Accepted: 16 October 2017 / Published: 20 October 2017
(This article belongs to the Special Issue Psoriasis)
View Full-Text   |   Download PDF [953 KB, uploaded 20 October 2017]   |  

Abstract

Recent years have seen considerable progress in explaining the mechanisms of the pathogenesis of psoriasis, with a significant role played in it by the hyper-reactivity of Th1 and Th17 cells, Treg function disorder, as well as complex relationships between immune cells, keratinocytes, and vascular endothelium. The effect of stem cells in the epidermis and stem cells on T cells has been identified and the dysfunction of various types of stem cells may be a prime cause of dysregulation of the inflammatory response in psoriasis. However, exploring these mechanisms in detail could provide a chance to develop new therapeutic strategies. In this paper, the authors reviewed data on the role played by stem cells in the pathogenesis of psoriasis and initial attempts at using them in treatment. View Full-Text
Keywords: psoriasis; umbilical cord-Wharton’s Jelly stem cells; mesenchymal stem cells psoriasis; umbilical cord-Wharton’s Jelly stem cells; mesenchymal stem cells
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Owczarczyk-Saczonek, A.; Krajewska-Włodarczyk, M.; Kruszewska, A.; Placek, W.; Maksymowicz, W.; Wojtkiewicz, J. Stem Cells as Potential Candidates for Psoriasis Cell-Replacement Therapy. Int. J. Mol. Sci. 2017, 18, 2182.

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