A Review: Expression of Aquaporins in Otitis Media
AbstractOtitis media (OM) refers to inflammatory diseases of the middle ear (ME), regardless of cause or pathological mechanism. Among the molecular biological studies assessing the pathology of OM are investigations of the expression of aquaporins (AQPs) in the ME and Eustachian tube (ET). To date, fifteen studies have evaluated AQPs expression in the ME and ET. Although the expression of individual AQPs varies by species and model, eleven types of AQP, AQP1 to AQP11, were found to be expressed in mammalian ME and ET. The review showed that: (1) various types of AQPs are expressed in the ME and ET; (2) AQP expression may vary by species; and (3) the distribution and levels of expression of AQPs may depend on the presence or absence of inflammation, with variations even in the same species and same tissue. Fluid accumulation in the ME and ET is a common pathological mechanism for all types of OM, causing edema in the tissue and inducing inflammation, thereby possibly involving various AQPs. The expression patterns of several AQPs, especially AQP1, 4 and 5, were found to be altered in response to inflammatory stimuli, including lipopolysaccharide (LPS), suggesting that AQPs may have immunological functions in OM. View Full-Text
Share & Cite This Article
Jung, S.Y.; Kim, S.S.; Kim, Y.I.; Kim, S.H.; Yeo, S.G. A Review: Expression of Aquaporins in Otitis Media. Int. J. Mol. Sci. 2017, 18, 2164.
Jung SY, Kim SS, Kim YI, Kim SH, Yeo SG. A Review: Expression of Aquaporins in Otitis Media. International Journal of Molecular Sciences. 2017; 18(10):2164.Chicago/Turabian Style
Jung, Su Young; Kim, Sung Su; Kim, Young Il; Kim, Sang Hoon; Yeo, Seung Geun. 2017. "A Review: Expression of Aquaporins in Otitis Media." Int. J. Mol. Sci. 18, no. 10: 2164.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.