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Int. J. Mol. Sci. 2017, 18(10), 2149; https://doi.org/10.3390/ijms18102149

Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair

1
Department of Plastic, Reconstructive & Aesthetic Surgery, University Hospitals of Geneva, 1205 Geneva, Switzerland
2
Department of Human Genetics and Development, Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland
3
SAMRC Extramural Unit for Stem Cell Research and Therapy, and Institute for Cellular and Molecular Medicine, Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria 0002, South Africa
*
Author to whom correspondence should be addressed.
Received: 22 September 2017 / Revised: 9 October 2017 / Accepted: 10 October 2017 / Published: 15 October 2017
(This article belongs to the Special Issue Free Radicals and Oxidants in Pathogenesis)
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Abstract

Our understanding of the role of oxygen in cell physiology has evolved from its long-recognized importance as an essential factor in oxidative metabolism to its recognition as an important player in cell signaling. With regard to the latter, oxygen is needed for the generation of reactive oxygen species (ROS), which regulate a number of different cellular functions including differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding wound contraction. In this review we provide an overview of the current literature on the role of molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions. View Full-Text
Keywords: reactive oxygen species; NADPH oxidase; NOX enzymes; wound repair; wound healing; chronic wounds; wound contraction; re-epithelialization; hyperbaric oxygen therapy; oxidative stress reactive oxygen species; NADPH oxidase; NOX enzymes; wound repair; wound healing; chronic wounds; wound contraction; re-epithelialization; hyperbaric oxygen therapy; oxidative stress
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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André-Lévigne, D.; Modarressi, A.; Pepper, M.S.; Pittet-Cuénod, B. Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair. Int. J. Mol. Sci. 2017, 18, 2149.

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