Prediction Potential of Serum miR-155 and miR-24 for Relapsing Early Breast Cancer
AbstractOncogenic microRNAs (oncomiRs) accumulate in serum due to their increased stability and thus serve as biomarkers in breast cancer (BC) pathogenesis. Four oncogenic microRNAs (miR-155, miR-19a, miR-181b, and miR-24) and one tumor suppressor microRNA (let-7a) were shown to differentiate between high- and low-risk early breast cancer (EBC) and reflect the surgical tumor removal and adjuvant therapy. Here we applied the longitudinal multivariate data analyses to stochastically model the serum levels of each of the oncomiRs using the RT-PCR measurements in the EBC patients (N = 133) that were followed up 4 years after diagnosis. This study identifies that two of the studied oncomiRs, miR-155 and miR-24, are highly predictive of EBC relapse. Furthermore, combining the oncomiR level with Ki-67 expression further specifies the relapse probability. Our data move further the notion that oncomiRs in serum enable not only monitoring of EBC but also are a very useful tool for predicting relapse independently of any other currently analyzed characteristics in EBC patients. Our approach can be translated into medical practice to estimate individual relapse risk of EBC patients. View Full-Text
- Supplementary File 1:
Supplementary (PDF, 321 KB)
Share & Cite This Article
Bašová, P.; Pešta, M.; Sochor, M.; Stopka, T. Prediction Potential of Serum miR-155 and miR-24 for Relapsing Early Breast Cancer. Int. J. Mol. Sci. 2017, 18, 2116.
Bašová P, Pešta M, Sochor M, Stopka T. Prediction Potential of Serum miR-155 and miR-24 for Relapsing Early Breast Cancer. International Journal of Molecular Sciences. 2017; 18(10):2116.Chicago/Turabian Style
Bašová, Petra; Pešta, Michal; Sochor, Marek; Stopka, Tomáš. 2017. "Prediction Potential of Serum miR-155 and miR-24 for Relapsing Early Breast Cancer." Int. J. Mol. Sci. 18, no. 10: 2116.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.