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Int. J. Mol. Sci. 2017, 18(1), 35; doi:10.3390/ijms18010035

The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy

1
Diabetes Complications Research Centre, Conway Institute, University College Dublin, Dublin 4, Ireland
2
Gastrosurgical Laboratory, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden
*
Author to whom correspondence should be addressed.
Academic Editors: Suzanne L. Dickson and Katalin Prokai-Tatrai
Received: 16 August 2016 / Revised: 11 December 2016 / Accepted: 19 December 2016 / Published: 26 December 2016
(This article belongs to the Special Issue Neurobiological Perspectives on Ghrelin)
View Full-Text   |   Download PDF [217 KB, uploaded 26 December 2016]

Abstract

Ghrelin, discovered in 1999, is a 28-amino-acid hormone, best recognized as a stimulator of growth hormone secretion, but with pleiotropic functions in the area of energy homeostasis, such as appetite stimulation and energy expenditure regulation. As the intrinsic ligand of the growth hormone secretagogue receptor (GHS-R), ghrelin appears to have a broad array of effects, but its primary role is still an area of debate. Produced mainly from oxyntic glands in the stomach, but with a multitude of extra-metabolic roles, ghrelin is implicated in complex neurobiological processes. Comprehensive studies within the areas of obesity and metabolic surgery have clarified the mechanism of these operations. As a stimulator of growth hormone (GH), and an apparent inducer of positive energy balance, other areas of interest include its impact on carcinogenesis and tumour proliferation and its role in the cancer cachexia syndrome. This has led several authors to study the hormone in the cancer setting. Ghrelin levels are acutely reduced following an oesophagectomy, a primary treatment modality for oesophageal cancer. We sought to investigate the nature of this postoperative ghrelin suppression, and its neurobiological implications. View Full-Text
Keywords: ghrelin; ghrelin suppression; GHS-R1A; oesophageal carcinoma; appetite; anticipatory feeding; reward-induced feeding; oesophagectomy ghrelin; ghrelin suppression; GHS-R1A; oesophageal carcinoma; appetite; anticipatory feeding; reward-induced feeding; oesophagectomy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Murphy, C.F.; le Roux, C.W. The Neurobiological Impact of Ghrelin Suppression after Oesophagectomy. Int. J. Mol. Sci. 2017, 18, 35.

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