Int. J. Mol. Sci. 2017, 18(1), 175; doi:10.3390/ijms18010175
Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds
Crina Saviuc 1,2,†, Bianca Ciubucă 1,2,†, Gabriela Dincă 3, Coralia Bleotu 1,4, Veronica Drumea 3, Mariana-Carmen Chifiriuc 1,*
, Marcela Popa 1, Gratiela Gradisteanu Pircalabioru 1, Luminita Marutescu 1 and Veronica Lazăr 1
, Marcela Popa 1, Gratiela Gradisteanu Pircalabioru 1, Luminita Marutescu 1 and Veronica Lazăr 11
Department of Botany-Microbiology, Research Institute of the University of Bucharest-ICUB, University of Bucharest, Faculty of Biology, SplaiulIndependenţei 91-95 Sector 5, 76201 Bucharest, Romania
2
S.C. SANIMED INTERNATIONAL IMPEX S.R.L., Sos. Bucuresti-Magurele, nr.70, Sector 5, 051434 Bucharest, Romania
3
S.C. Biotehnos S.A., Gorunului Str. 3-5, 075100 Otopeni, Ilfov, Romania
4
Ştefan S. Nicolau Institute of Virology, 285 Mihai Bravu Avenue, Sector 3, 030304 Bucharest, Romania
†
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 30 October 2016 / Revised: 5 January 2017 / Accepted: 10 January 2017 / Published: 17 January 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions)
Abstract
The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i.e., eugenol, β-pinene, eucalyptol, and limonene) and anti-inflammatory agents for potential use in the topical treatment of acne and other skin infections. The optimal antimicrobial combinations selected in this study were eugenol/β-pinene/salicylic acid and eugenol/β-pinene/2-phenoxyethanol/potassium sorbate. The possible mechanisms of action revealed by flow cytometry were cellular permeabilization and inhibition of efflux pumps activity induced by concentrations corresponding to sub-minimal inhibitory (sub-MIC) values. The most active antimicrobial combination represented by salycilic acid/eugenol/β-pinene/2-phenoxyethanol/potassium sorbate was included in a cream base, which demonstrated thermodynamic stability and optimum microbiological characteristics. View Full-TextKeywords:
plant-derived compounds; antimicrobial; acne; eugenol; β-pinene; eucalyptol; limonene
▼
Figures
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Scifeed alert for new publications
Never miss any articles matching your research from any publisher- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Share & Cite This Article
MDPI and ACS Style
Saviuc, C.; Ciubucă, B.; Dincă, G.; Bleotu, C.; Drumea, V.; Chifiriuc, M.-C.; Popa, M.; Gradisteanu Pircalabioru, G.; Marutescu, L.; Lazăr, V. Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds. Int. J. Mol. Sci. 2017, 18, 175.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
Related Articles
Article Metrics
Comments
[Return to top]
Int. J. Mol. Sci.
EISSN 1422-0067
Published by MDPI AG, Basel, Switzerland
RSS
E-Mail Table of Contents Alert