Int. J. Mol. Sci. 2017, 18(1), 175; doi:10.3390/ijms18010175
Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds
Crina Saviuc 1,2,†, Bianca Ciubucă 1,2,†, Gabriela Dincă 3, Coralia Bleotu 1,4
, Veronica Drumea 3, Mariana-Carmen Chifiriuc 1,*
, Marcela Popa 1, Gratiela Gradisteanu Pircalabioru 1, Luminita Marutescu 1 and Veronica Lazăr 1
, Veronica Drumea 3, Mariana-Carmen Chifiriuc 1,*
, Marcela Popa 1, Gratiela Gradisteanu Pircalabioru 1, Luminita Marutescu 1 and Veronica Lazăr 11
Department of Botany-Microbiology, Research Institute of the University of Bucharest-ICUB, University of Bucharest, Faculty of Biology, SplaiulIndependenţei 91-95 Sector 5, 76201 Bucharest, Romania
2
S.C. SANIMED INTERNATIONAL IMPEX S.R.L., Sos. Bucuresti-Magurele, nr.70, Sector 5, 051434 Bucharest, Romania
3
S.C. Biotehnos S.A., Gorunului Str. 3-5, 075100 Otopeni, Ilfov, Romania
4
Ştefan S. Nicolau Institute of Virology, 285 Mihai Bravu Avenue, Sector 3, 030304 Bucharest, Romania
†
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Chris Jackson
Received: 30 October 2016 / Revised: 5 January 2017 / Accepted: 10 January 2017 / Published: 17 January 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions)
Abstract
The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i.e., eugenol, β-pinene, eucalyptol, and limonene) and anti-inflammatory agents for potential use in the topical treatment of acne and other skin infections. The optimal antimicrobial combinations selected in this study were eugenol/β-pinene/salicylic acid and eugenol/β-pinene/2-phenoxyethanol/potassium sorbate. The possible mechanisms of action revealed by flow cytometry were cellular permeabilization and inhibition of efflux pumps activity induced by concentrations corresponding to sub-minimal inhibitory (sub-MIC) values. The most active antimicrobial combination represented by salycilic acid/eugenol/β-pinene/2-phenoxyethanol/potassium sorbate was included in a cream base, which demonstrated thermodynamic stability and optimum microbiological characteristics. View Full-TextKeywords:
plant-derived compounds; antimicrobial; acne; eugenol; β-pinene; eucalyptol; limonene
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Saviuc, C.; Ciubucă, B.; Dincă, G.; Bleotu, C.; Drumea, V.; Chifiriuc, M.-C.; Popa, M.; Gradisteanu Pircalabioru, G.; Marutescu, L.; Lazăr, V. Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds. Int. J. Mol. Sci. 2017, 18, 175.
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