Next Article in Journal
Influence of Anode Potentials on Current Generation and Extracellular Electron Transfer Paths of Geobacter Species
Next Article in Special Issue
Pancreatic Neuroendocrine Neoplasms: Basic Biology, Current Treatment Strategies and Prospects for the Future
Previous Article in Journal
Pneumococcal Colonization in the Familial Context and Implications for Anti-Pneumococcal Immunization in Adults: Results from the BINOCOLO Project in Sicily
Previous Article in Special Issue
Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2017, 18(1), 106; doi:10.3390/ijms18010106

The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies

1
Department of Diagnostics, University Hospital, 31-501 Kraków, Poland
2
Department of Medical Diagnostics, Jagiellonian University Medical College, 30-688 Kraków, Poland
3
Department of Anatomy, Jagiellonian University Medical College, 31-034 Kraków, Poland
4
2nd Department of Surgery, Jagiellonian University Medical College, 31-501 Kraków, Poland
5
Surgery Department, The District Hospital, 34-200 Sucha Beskidzka, Poland
6
Department of Physiology, Jagiellonian University Medical College, 31-531 Kraków, Poland
7
Department of Pharmacology, Jagiellonian University Medical College, 31-531 Kraków, Poland
8
Chair and Department of Nephrology, Jagiellonian University Medical College, 31-501 Kraków, Poland
9
Department of Diagnostics, Chair of Clinical Biochemistry, Jagiellonian University Medical College, 31-501 Kraków, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Srikumar Chellappan
Received: 2 October 2016 / Revised: 26 December 2016 / Accepted: 29 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Pancreatic Disorders)
View Full-Text   |   Download PDF [1294 KB, uploaded 6 January 2017]   |  

Abstract

The most common causes of acute pancreatitis (AP) are biliary tract diseases with cholestasis and alcohol consumption. In 10%–15% of patients, etiology determination is difficult. Identification of the etiology allows for the implementation of adequate treatment. The aim of this study was to assess the utility of the serum concentrations of total bile acids (TBA) to diagnose AP etiology in the early phase of the disease. We included 66 patients with AP, admitted within the first 24 h from the onset of symptoms. TBA were measured in serum at 24, 48, and 72 h from the onset of AP, using an automated fifth generation assay. The bilirubin-to-TBA ratio (B/TBA) was calculated. TBA was highest on the first day of AP and decreased subsequently. In patients with biliary etiology, serum TBA was significantly higher compared to those with alcoholic and other etiologies. B/TBA was significantly higher in patients with alcoholic etiology. At admission, the cut-off values of 4.7 µmol/L for TBA and 4.22 for the B/TBA ratio allowed for a differentiation between biliary and other etiologies of AP with a diagnostic accuracy of 85 and 83%. Both TBA and B/TBA may help in the diagnosis of AP etiology in the early phase of AP. View Full-Text
Keywords: idiopathic acute pancreatitis; total bile acids; biliary acute pancreatitis idiopathic acute pancreatitis; total bile acids; biliary acute pancreatitis
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Maleszka, A.; Dumnicka, P.; Matuszyk, A.; Pędziwiatr, M.; Mazur-Laskowska, M.; Sporek, M.; Ceranowicz, P.; Olszanecki, R.; Kuźniewski, M.; Kuśnierz-Cabala, B. The Diagnostic Usefulness of Serum Total Bile Acid Concentrations in the Early Phase of Acute Pancreatitis of Varied Etiologies. Int. J. Mol. Sci. 2017, 18, 106.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top