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Int. J. Mol. Sci. 2016, 17(9), 1460; doi:10.3390/ijms17091460

Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori

1
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China
2
Department of Biochemistry & Molecular Biology, Chongqing Medical University, Chongqing 400016, China
*
Author to whom correspondence should be addressed.
Academic Editor: Kun Yan Zhu
Received: 23 July 2016 / Revised: 25 August 2016 / Accepted: 26 August 2016 / Published: 20 September 2016
(This article belongs to the Section Biochemistry, Molecular and Cellular Biology)
View Full-Text   |   Download PDF [1036 KB, uploaded 20 September 2016]   |  

Abstract

The head, which performs many biological functions, is the most complicated structure of an insect. Development, locomotor behavior, food intake, environmental sensing, and signal transduction are all controlled by the insect’s head. As a well-studied insect in Lepidoptera, the silkworm head has an additional function of spinning silk fibers. To understand which molecules are involved in these physiological activities, we performed a metabolomics analysis of silkworm heads. By integrating GC-MS and LC-MS/MS, 90 metabolites were identified in the larval heads of silkworms. These were classified into 13 categories, including amino acids, sugars, organic acids, nucleotides, alcohols, and fatty acids. Informatics analysis revealed that these metabolites are involved in cellular processes, environmental information processing, genetic information processing, human diseases, metabolism, organismal systems, and other pathways. The identified metabolites and pathways are involved in biological processes such as signal transduction, carbohydrate metabolism, endocrine activities, and sensory activities; reflecting the functions of various organs in silkworm heads. Thus, our findings provide references which elucidate the potential functions of the silkworm head and will be of great value for the metabolomics research of silkworms and other insects. View Full-Text
Keywords: metabolites; pathway analysis; GC-MS; LC-MS/MS; head; silkworm metabolites; pathway analysis; GC-MS; LC-MS/MS; head; silkworm
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, Y.; Wang, X.; Chen, Q.; Hou, Y.; Xia, Q.; Zhao, P. Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori. Int. J. Mol. Sci. 2016, 17, 1460.

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