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Int. J. Mol. Sci. 2016, 17(9), 1406; doi:10.3390/ijms17091406

Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells

Department of Food and Biotechnology, Korea University, 2511 Sejongro, Jochiwon, Sejong 339-700, Korea
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Academic Editor: Maurizio Battino
Received: 27 June 2016 / Revised: 27 June 2016 / Accepted: 22 August 2016 / Published: 26 August 2016
(This article belongs to the Section Bioactives and Nutraceuticals)
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Abstract

Our work aimed to investigate the protective effects of saponin-based nanoemulsions of vitamin A and E against oxidative stress-induced cellular damage in AML-12 cells. Saponin nanoemulsions of vitamin A (SAN) and vitamin E (SEN) were prepared by high-pressure homogenization and characterized in terms of size, zeta potential, and polydispersity index. SEN and SAN protect AML-12 cells against oxidative stress-induced cellular damage more efficiently via scavenging reactive oxygen species (ROS), and reducing DNA damage, protein carbonylation, and lipid peroxidation. These results provide valuable information for the development of nanoemulsion-based delivery systems that would improve the antioxidant properties of vitamin A and E. View Full-Text
Keywords: vitamin A; vitamin E; nanoemulsification; saponin; antioxidant capacity vitamin A; vitamin E; nanoemulsification; saponin; antioxidant capacity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choudhry, Q.N.; Kim, M.J.; Kim, T.G.; Pan, J.H.; Kim, J.H.; Park, S.J.; Lee, J.H.; Kim, Y.J. Saponin-Based Nanoemulsification Improves the Antioxidant Properties of Vitamin A and E in AML-12 Cells. Int. J. Mol. Sci. 2016, 17, 1406.

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