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Int. J. Mol. Sci. 2016, 17(8), 1286; doi:10.3390/ijms17081286

Phylogenetic-Derived Insights into the Evolution of Sialylation in Eukaryotes: Comprehensive Analysis of Vertebrate β-Galactoside α2,3/6-Sialyltransferases (ST3Gal and ST6Gal)

1
Bioinformatics Unit, Fundación Instituto Leloir, Av. Patricias Argentinas 435, C1405BWE Buenos Aires, Argentina
2
Laboratoire de Génétique Moléculaire Animale, UMR 1061 INRA, Université de Limoges Faculté des Sciences et Techniques, 123 avenue Albert Thomas, 87060 Limoges, France
3
FRABio-FR3688 CNRS, Univ. Lille, bât. C9, 59655 Villeneuve d’Ascq cedex, France
4
Univ. Lille, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, 59000 Lille, France
5
UGSF, Bât. C9, Université de Lille-Sciences et Technologies, 59655 Villeneuve d’Ascq, France
*
Author to whom correspondence should be addressed.
Academic Editor: Cheorl-Ho Kim
Received: 28 June 2016 / Revised: 26 July 2016 / Accepted: 28 July 2016 / Published: 9 August 2016
(This article belongs to the Special Issue Glycan–Receptor Interaction)
View Full-Text   |   Download PDF [6694 KB, uploaded 9 August 2016]   |  

Abstract

Cell surface of eukaryotic cells is covered with a wide variety of sialylated molecules involved in diverse biological processes and taking part in cell–cell interactions. Although the physiological relevance of these sialylated glycoconjugates in vertebrates begins to be deciphered, the origin and evolution of the genetic machinery implicated in their biosynthetic pathway are poorly understood. Among the variety of actors involved in the sialylation machinery, sialyltransferases are key enzymes for the biosynthesis of sialylated molecules. This review focus on β-galactoside α2,3/6-sialyltransferases belonging to the ST3Gal and ST6Gal families. We propose here an outline of the evolutionary history of these two major ST families. Comparative genomics, molecular phylogeny and structural bioinformatics provided insights into the functional innovations in sialic acid metabolism and enabled to explore how ST-gene function evolved in vertebrates. View Full-Text
Keywords: evolution; sialyltransferases; sialic acid; molecular phylogeny; functional genomics evolution; sialyltransferases; sialic acid; molecular phylogeny; functional genomics
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Teppa, R.E.; Petit, D.; Plechakova, O.; Cogez, V.; Harduin-Lepers, A. Phylogenetic-Derived Insights into the Evolution of Sialylation in Eukaryotes: Comprehensive Analysis of Vertebrate β-Galactoside α2,3/6-Sialyltransferases (ST3Gal and ST6Gal). Int. J. Mol. Sci. 2016, 17, 1286.

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