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Int. J. Mol. Sci. 2016, 17(8), 1270; doi:10.3390/ijms17081270

Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection

1
Laboratório de Patologia e Biointervenção, Instituto Gonçalo Moniz, FIOCRUZ, Salvador 40296-710, Brazil
2
Instituto Nacional de Ciência e Tecnologia para Doenças Tropicais (INCT-DT), Salvador 40110-160, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: David Sheehan
Received: 1 May 2016 / Revised: 21 June 2016 / Accepted: 26 July 2016 / Published: 19 August 2016
(This article belongs to the Collection Advances in Proteomic Research)
View Full-Text   |   Download PDF [1970 KB, uploaded 19 August 2016]   |  

Abstract

Leishmania is a protozoan parasite that causes a wide range of different clinical manifestations in mammalian hosts. It is a major public health risk on different continents and represents one of the most important neglected diseases. Due to the high toxicity of the drugs currently used, and in the light of increasing drug resistance, there is a critical need to develop new drugs and vaccines to control Leishmania infection. Over the past few years, proteomics has become an important tool to understand the underlying biology of Leishmania parasites and host interaction. The large-scale study of proteins, both in parasites and within the host in response to infection, can accelerate the discovery of new therapeutic targets. By studying the proteomes of host cells and tissues infected with Leishmania, as well as changes in protein profiles among promastigotes and amastigotes, scientists hope to better understand the biology involved in the parasite survival and the host-parasite interaction. This review demonstrates the feasibility of proteomics as an approach to identify new proteins involved in Leishmania differentiation and intracellular survival. View Full-Text
Keywords: proteomics; Leishmania; intracellular survival proteomics; Leishmania; intracellular survival
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Veras, P.S.T.; Bezerra de Menezes, J.P. Using Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish Infection. Int. J. Mol. Sci. 2016, 17, 1270.

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