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Int. J. Mol. Sci. 2016, 17(8), 1202; doi:10.3390/ijms17081202

Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans

1
Department of Physiology, Institute of Nutrition and Food Technology “Jose Mataix”, University of Granada, Biomedical Research Center, Avda. Conocimiento s/n, 18100 Armilla, Spain
2
Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche (DISCO)-Sez. Biochimica, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy
3
Department of Stomalogy, Dental School, University of Sevilla, C/Avicena s/n, 41009 Sevilla, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Vito Verardo
Received: 1 June 2016 / Revised: 8 July 2016 / Accepted: 20 July 2016 / Published: 25 July 2016
(This article belongs to the Special Issue Macro- and Micro-nutrient Antioxidants)
View Full-Text   |   Download PDF [1120 KB, uploaded 25 July 2016]   |  

Abstract

The risk of different oral problems (root caries, tooth mobility, and tooth loss) can be increased by the presence of periodontal disease, which has also been associated with a growing list of systemic diseases. The presence of some bacteria is the primary etiology of this disease; a susceptible host is also necessary for disease initiation. In this respect, the progression of periodontal disease and healing of the periodontal tissues can be modulated by nutritional status. To clarify the role of lipids in the establishment, progression, and/or treatment of this pathology, a systematic review was conducted of English-written literature in PubMed until May 2016, which included research on the relationship of these dietary components with the onset and progression of periodontal disease. According to publication type, randomized-controlled trials, cohort, case-control and cross-sectional studies were included. Among all the analyzed components, those that have any effect on oxidative stress and/or inflammation seem to be the most interesting according to current evidence. On one hand, there is quite a lot of information in favor of a positive role of n-3 fatty acids, due to their antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided. View Full-Text
Keywords: diet; fatty acids; polyunsaturated fatty acids (PUFA); nutrition; oral health; periodontitis diet; fatty acids; polyunsaturated fatty acids (PUFA); nutrition; oral health; periodontitis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Varela-López, A.; Giampieri, F.; Bullón, P.; Battino, M.; Quiles, J.L. Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans. Int. J. Mol. Sci. 2016, 17, 1202.

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