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Int. J. Mol. Sci. 2016, 17(7), 1163; doi:10.3390/ijms17071163

Current Stem Cell Biomarkers and Their Functional Mechanisms in Prostate Cancer

1
The Department of Urology, Affiliated Sixth People’s Hospital, Shanghai JiaoTong University, Shanghai 200233, China
2
Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA
3
VIP Department of Beijing Hospital, Beijing 100730, China
4
Urology Department of Beijing Hospital, Beijing 100730, China
5
Department of Cancer Biology, Wake Forest University School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA
These authors contributed equally to this work.
Current address: New York Genome Center, 101 Avenue of the Americas, New York, NY 10013, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Carsten Stephan
Received: 30 May 2016 / Revised: 7 July 2016 / Accepted: 9 July 2016 / Published: 19 July 2016
(This article belongs to the Special Issue Diagnostic, Prognostic and Predictive Biomarkers in Prostate Cancer)
View Full-Text   |   Download PDF [2017 KB, uploaded 19 July 2016]   |  

Abstract

Currently there is little effective treatment available for castration resistant prostate cancer, which is responsible for the majority of prostate cancer related deaths. Emerging evidence suggested that cancer stem cells might play an important role in resistance to traditional cancer therapies, and the studies of cancer stem cells (including specific isolation and targeting on those cells) might benefit the discovery of novel treatment of prostate cancer, especially castration resistant disease. In this review, we summarized major biomarkers for prostate cancer stem cells, as well as their functional mechanisms and potential application in clinical diagnosis and treatment of patients. View Full-Text
Keywords: prostate cancer; cancer stem cell; stem cell biomarker prostate cancer; cancer stem cell; stem cell biomarker
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Zhang, K.; Zhou, S.; Wang, L.; Wang, J.; Zou, Q.; Zhao, W.; Fu, Q.; Fang, X. Current Stem Cell Biomarkers and Their Functional Mechanisms in Prostate Cancer. Int. J. Mol. Sci. 2016, 17, 1163.

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